SCHEMBL3097671

SCHEMBL3097671

Cn1nc(O[C@@H]2c3cc(S(=O)(=O)c4cccc(O)c4)ccc3OC(C)(C)[C@@]2(C)O)ccc1=O

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 3/20 0.33
ABCC9 O60706 8/20 0.33
AXL P30530 5/20 0.32
TYRO3 Q06418 5/20 0.32
MERTK Q12866 5/20 0.32
PKM P14618 1/20 0.31
ABCC8 Q09428 1/20 0.30
KCNJ11 Q14654 1/20 0.30
KCNJ8 Q15842 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5338954 1.00 HTR6 (0.33) HTR6ABCC9AXLTYRO3MERTK
Water SCHEMBL5002583 0.99 HTR6 (0.33) HTR6ABCC9AXLTYRO3MERTK
SCHEMBL14336961 0.92 HTR6 (0.34) HTR6ABCC9AXLTYRO3MERTK
SCHEMBL8148145 0.92 ABCC9 (0.34) HTR6ABCC9AXLTYRO3MERTK
SCHEMBL5341621 0.92 ABCC9 (0.34) HTR6ABCC9AXLTYRO3MERTK
SCHEMBL8142517 0.90 AXL (0.33) ABCC9AXLTYRO3MERTK
SCHEMBL8142354 0.87 HTR6 (0.34) HTR6ABCC9AXLTYRO3MERTK
SCHEMBL8149616 0.86 POLB (0.38) ABCC9AXLTYRO3MERTK
SCHEMBL8147486 0.81 ABCC9 (0.33) ABCC9
SCHEMBL9150597 0.80 TRPV1 (0.34) AXLTYRO3MERTKPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7655656-B2 Hair growth promoting agents PFIZER INC. (US) 2010-02-02 US claimed
US-20090209548-A1 FORMULATION FOR STIMULATING HAIR GROWTH PFIZER INC 2009-08-20 US claimed
US-20080318967-A1 Hair Growth Promoting Agents PFIZER INC. (US) 2008-12-25 US claimed
EP-1562547-B1 METHOD OF STIMULATING HAIR GROWTH USING BENZOPYRANS WARNER LAMBERT CO (US) 2008-09-10 EP claimed
US-7306789-B2 Method of stimulating hair growth using benzopyrans WARNER-LAMBERT COMPANY, LLC (US) 2007-12-11 US claimed
US-20070225357-A1 Formulation for Stimulating Hair Growth PFIZER INC. (US) 2007-09-27 US claimed
EP-1778216-A1 FORMULATION FOR STIMULATING HAIR GROWTH Warner-Lambert Company LLC (US) 2007-05-02 EP claimed
EP-1773820-A1 HAIR GROWTH PROMOTING AGENTS Warner-Lambert Company LLC (US) 2007-04-18 EP claimed
WO-2006011046-A1 FORMULATION FOR STIMULATING HAIR GROWTH WARNER-LAMBERT COMPANY LLC (US) 2006-02-02 WO claimed
WO-2006008641-A1 HAIR GROWTH PROMOTING AGENTS WARNER-LAMBERT COMPANY LLC (US) 2006-01-26 WO claimed
EP-1562547-A1 METHOD OF STIMULATING HAIR GROWTH USING BENZOPYRANS Warner-Lambert Company LLC (US) 2005-08-17 EP claimed
US-20040157856-A1 Method of stimulating hair growth using benzopyrans DOHERTY NIALL STEPHEN (US) 2004-08-12 US claimed
WO-2004043424-A1 METHOD OF STIMULATING HAIR GROWTH USING BENZOPYRANS WARNER-LAMBERT COMPANY LLC (US) 2004-05-27 WO claimed
US-5912244-A MUSCLE DISORDERS, BREATHING DISORDERS AND URINARY INCONTINENCE PFIZER INC. (US) 1999-06-15 US claimed
EP-0712398-B1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PFIZER LTD (GB) 1997-05-07 EP claimed
US-7799823-B2 Androgen modulators WARNER-LAMBERT COMPANY LLC (US) 2010-09-21 US disclosed
US-7674819-B2 Androgen modulators WARNER-LAMBERT COMPANY LLC (US) 2010-03-09 US disclosed
EP-0712398-B1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PFIZER LTD (GB) 1997-05-07 EP disclosed
EP-0712398-A1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PFIZER LTD (GB) 1996-05-22 EP disclosed
WO-1995004730-A1 BENZOPYRANS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PFIZER LIMITED (GB) 1995-02-16 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090209548-A1 FORMULATION FOR STIMULATING HAIR GROWTH SRD5A2, HSD17B7, HDGF HTR6 41/4885ABCC9 4434/4885AXL 2995/4885
US-20080318967-A1 Hair Growth Promoting Agents HDGF, NGF, MKI67 HTR6 331/4885ABCC9 4847/4885AXL 4214/4885
US-20070225357-A1 Formulation for Stimulating Hair Growth SRD5A2, HSD17B7, SRD5A1 HTR6 42/4885ABCC9 4389/4885AXL 2977/4885
US-20040157856-A1 Method of stimulating hair growth using benzopyrans FGF1, HDGF, NGF HTR6 383/4885ABCC9 4687/4885AXL 3394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.