Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989967 | 1.00 | RIPK1 (0.44) | RIPK1GPBAR1NPC1RAB9ANLRP3 | |
| SCHEMBL30989781 | 0.89 | RIPK1 (0.46) | RIPK1GPBAR1NPC1NLRP3MAPT | |
| SCHEMBL30989822 | 0.89 | RIPK1 (0.42) | RIPK1NLRP3MAPTMEN1KMT2A | |
| SCHEMBL30989786 | 0.88 | RXFP1 (0.45) | RIPK1GPBAR1MAPTMEN1KMT2A | |
| SCHEMBL30989921 | 0.84 | RIPK1 (0.45) | RIPK1GPBAR1NLRP3MAPTGAA | |
| SCHEMBL30989909 | 0.82 | CLK1 (0.48) | RIPK1MEN1KMT2AHSP90AA1ALDH1A1 | |
| SCHEMBL30989848 | 0.81 | MAPT (0.43) | GPBAR1MAPTMEN1KMT2ARXFP1 | |
| SCHEMBL30989882 | 0.80 | MEN1 (0.48) | RIPK1NPC1RAB9ANLRP3MAPT | |
| SCHEMBL30989930 | 0.80 | HSP90AA1 (0.52) | MEN1KMT2ARXFP1GAAHSP90AA1 | |
| SCHEMBL30990047 | 0.80 | MET (0.51) | RIPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |