Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GPR6 | P46095 | 2/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30989880 | 0.84 | LRRK2 (0.37) | PIK3C3RIPK1MAPTGPR6GPBAR1 | |
| SCHEMBL30989869 | 0.84 | LRRK2 (0.37) | PIK3C3RIPK1MAPTGPR6GPBAR1 | |
| SCHEMBL30989936 | 0.82 | RIPK1 (0.47) | PIK3C3RIPK1MAPTGPR6GPBAR1 | |
| SCHEMBL30989882 | 0.77 | MEN1 (0.48) | PIK3C3RIPK1MAPTMEN1KMT2A | |
| SCHEMBL30989781 | 0.76 | RIPK1 (0.46) | PIK3C3RIPK1MAPTGPBAR1MEN1 | |
| SCHEMBL30989864 | 0.75 | CLK1 (0.51) | RIPK1MEN1KMT2AGAAPOLB | |
| SCHEMBL30989827 | 0.73 | PIK3C3 (0.41) | PIK3C3RIPK1MAPTGPR6GPBAR1 | |
| SCHEMBL30989901 | 0.73 | RIPK1 (0.46) | PIK3C3RIPK1MAPTGPR6MEN1 | |
| SCHEMBL2594687 | 0.73 | GPBAR1 (0.41) | PIK3C3GPR6GPBAR1MGLL | |
| SCHEMBL30989921 | 0.72 | RIPK1 (0.45) | PIK3C3RIPK1MAPTGPR6GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4612131-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2025-09-10 | — | — | EP | disclosed |
| WO-2024095003-A1 | NICOTINAMIDE DERIVATIVES FOR USE IN TREATING DISORDERS ASSOCIATED WITH KCNK13 ACTIVITY | Cerevance, Inc. (US) | 2024-05-10 | — | — | WO | disclosed |