Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2639674 | 0.82 | TRPV4 (0.42) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| Ethylene SCHEMBL27960950 | 0.79 | MAOB (0.50) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL573864 | 0.78 | MAOB (0.53) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL3227308 | 0.77 | AHR (0.30) | ALDH1A1CYP1A2 | |
| SCHEMBL74807 | 0.76 | TRPV4 (0.46) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL4824074 | 0.76 | TRPV4 (0.31) | TRPV4 | |
| SCHEMBL21116203 | 0.76 | USP8 (0.42) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL16957602 | 0.76 | MAOA (0.43) | TRPV4MAOAMAOBCYP11B2CYP11B1 | |
| SCHEMBL1311361 | 0.74 | IMPDH2 (0.41) | ALDH1A1CLK4 | |
| SCHEMBL101523 | 0.73 | TSHR (0.48) | TRPV4MAOAMAOBCYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 184 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909198-B1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | ASTEX THERAPEUTICS LTD (GB) | 2020-10-14 | — | — | EP | claimed |
| EP-2909197-B1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | ASTEX THERAPEUTICS LTD (GB) | 2020-03-04 | — | — | EP | claimed |
| CN-104870442-B | bicyclic heterocyclic compounds and their therapeutic use | 阿斯特克斯治疗有限公司 | 2018-10-19 | — | — | CN | claimed |
| US-9980973-B2 | Bicyclic heterocycle compounds and their uses in therapy | ASTEX THERAPEUTICS LIMITED (GB) | 2018-05-29 | — | — | US | claimed |
| EP-2119717-B1 | 8-[3-amino-piperidin-1-yl]-xanthins, their production and utilisation as DPP IV inhibitors | BOEHRINGER INGELHEIM INT (DE) | 2018-01-17 | — | — | EP | claimed |
| US-20170224705-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | ASTEX THERAPEUTICS LIMITED (GB) | 2017-08-10 | — | — | US | claimed |
| US-9663512-B2 | Bicyclic heterocycle compounds and their uses in therapy | ASTEX THERAPEUTICS LIMITED (GB) | 2017-05-30 | — | — | US | claimed |
| US-20150266873-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | ASTEX THERAPEUTICS LIMITED (GB) | 2015-09-24 | — | — | US | claimed |
| EP-2909197-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | Astex Therapeutics Ltd. (GB) | 2015-08-26 | — | — | EP | claimed |
| EP-2909198-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | Astex Therapeutics Limited (GB) | 2015-08-26 | — | — | EP | claimed |
| EP-1411940-A1 | BRIDGED PIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2004-04-28 | — | — | EP | claimed |
| WO-2004024720-A1 | PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2004-03-25 | — | — | WO | claimed |
| JP-2003528088-A | — | — | 2003-09-24 | — | — | JP | claimed |
| WO-2003007949-A1 | BRIDGED PIPERIDINE DERIVATIVES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2003-01-30 | — | — | WO | claimed |
| EP-1268449-A1 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS | Merck & Co., Inc. (US) | 2003-01-02 | — | — | EP | claimed |
| US-6458790-B2 | DIETETICS; ANTIDABETIC AGENTS; SEXUAL DISRDERS | MERCK & CO., INC. | 2002-10-01 | — | — | US | claimed |
| US-20020019523-A1 | Substituted piperidines as melanocortin receptor agonists | MERCK SHARP & DOHME CORP. | 2002-02-14 | — | — | US | claimed |
| WO-2001070708-A1 | SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS | MERCK & CO., INC. (US) | 2001-09-27 | — | — | WO | claimed |
| CN-1024316-C | Imidazole fungicides | SCHERING AGROCHEMICALS LTD (GB) | 1994-04-27 | — | — | CN | claimed |
| CN-1051729-A | IMIDAZOLE FUNGICIDES | SCHERING AGROCHEMICALS LTD (GB) | 1991-05-29 | — | — | CN | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266873-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | PC, BAD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TRPV4 2761/4885MAOA 1102/4885MAOB 489/4885 |
| US-20170224705-A1 | BICYCLIC HETEROCYCLE COMPOUNDS AND THEIR USES IN THERAPY | PC, BAD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | TRPV4 2761/4885MAOA 1102/4885MAOB 489/4885 |
| US-20020019523-A1 | Substituted piperidines as melanocortin receptor agonists | MC4R, MC5R, MC3R | TRPV4 125/4885MAOA 1819/4885MAOB 2009/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.