Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TRPC5 | Q9UL62 | 5/20 | 0.48 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.43 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18834083 | 0.84 | TRPC5 (0.49) | TRPC5TRPC4KCNH2TP53TRPC1 | |
| SCHEMBL30149464 | 0.81 | LMNA (0.70) | LMNAMAPK1TRPC5PDE4APDE4B | |
| SCHEMBL31042913 | 0.78 | LMNA (0.56) | LMNAMAPK1TRPC5PDE4APDE4B | |
| SCHEMBL555209 | 0.78 | PDE1A (0.64) | LMNAMAPK1PDE4APDE4BPDE4C | |
| SCHEMBL31052938 | 0.78 | TRPC5 (0.42) | MAPK1TRPC5TRPC4KCNH2POLB | |
| SCHEMBL19374965 | 0.77 | ADORA3 (0.51) | LMNAMAPK1TRPC5TRPC4KCNH2 | |
| SCHEMBL21242794 | 0.76 | KMT2A (0.67) | MAPK1POLBALDH1A1MEN1KMT2A | |
| SCHEMBL16076186 | 0.76 | MAPT (0.43) | MAPK1TRPC5TRPC4KCNH2POLB | |
| SCHEMBL19505597 | 0.72 | SMN1; SMN2 (0.38) | LMNAMAPK1TRPC5TRPC4KCNH2 | |
| SCHEMBL31052954 | 0.71 | P2RX3 (0.42) | POLBALDH1A1TP53KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118373832-B | Macrocyclic compound, pharmaceutical composition and application thereof | 深圳晶蛋生物医药科技有限公司 | 2025-01-28 | — | — | CN | disclosed |
| CN-118373832-A | Macrocyclic compound, pharmaceutical composition and application thereof | 深圳晶蛋生物医药科技有限公司 | 2024-07-23 | — | — | CN | disclosed |