Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.61 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.61 |
| ▸ | WNT3A | P56704 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SCD | O00767 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30222 | 0.80 | HSD17B1 (0.79) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL31001 | 0.77 | SCD (0.76) | NPC1RAB9AMEN1KMT2ASCD | |
| SCHEMBL30192 | 0.76 | HSD17B1 (1.00) | HSD17B1HSD17B2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL24730459 | 0.72 | HSD17B1 (0.60) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL29947433 | 0.72 | HSD17B1 (0.60) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL16623335 | 0.71 | APP (0.54) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL30687 | 0.69 | HSD17B1 (1.00) | HSD17B1HSD17B2NPC1RAB9AMEN1 | |
| SCHEMBL30962505 | 0.69 | KMT2A (0.51) | WNT3ANPC1RAB9AMEN1KMT2A | |
| SCHEMBL4568348 | 0.68 | MLYCD (0.48) | RAB9AMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL9036775 | 0.68 | LMNA (0.55) | WNT3ANPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609089-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012025638-A1 | SELECTIVE 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1 INHIBITORS | Universität des Saarlandes (DE) | 2012-03-01 | — | — | WO | disclosed |