Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | GHSR | Q92847 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7173488 | 0.82 | ALDH1A1 (0.66) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL3106332 | 0.81 | ALDH1A1 (0.54) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL3106340 | 0.74 | PTGS2 (0.53) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL1224858 | 0.72 | ALDH1A1 (1.00) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL1224417 | 0.72 | ALDH1A1 (0.77) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL7058846 | 0.70 | TSHR (0.72) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL3267048 | 0.70 | ALDH1A1 (0.52) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL3637872 | 0.70 | GHSR (0.80) | PTGS2GHSR | |
| SCHEMBL1225210 | 0.69 | ALDH1A1 (0.72) | ALDH1A1MAPTGAAKDM4ETDP1 | |
| SCHEMBL1225674 | 0.69 | ALDH1A1 (0.71) | ALDH1A1MAPTGAAKDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | PILLARISETTI SIVARAM (US) | 2005-05-05 | — | — | US | claimed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | claimed |
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM | 2003-03-06 | — | — | US | claimed |
| US-8193177-B2 | Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases | ANGION BIOMEDICA CORP. (US) | 2012-06-05 | — | — | US | disclosed |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. | 2010-10-07 | — | — | US | disclosed |
| WO-2009064422-A2 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | ANGION BIOMEDICA CORP. (US) | 2009-05-22 | — | — | WO | disclosed |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | PILLARISETTI SIVARAM (US) | 2005-05-05 | — | — | US | disclosed |
| US-6855728-B2 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | NORTH SHORE-LONG ISLAND JEWISH HEALTH SYSTEM (US) | 2005-02-15 | — | — | US | disclosed |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | THE FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045559-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | ALDH1A1 510/4885MAPT 4612/4885GAA 2947/4885 |
| US-20030216459-A1 | Small-molecule modulators of hepatocyte growth factor / scatter factor activities | HGF, HDGF, MET | ALDH1A1 510/4885MAPT 4612/4885GAA 2947/4885 |
| US-20050096372-A1 | Small-molecule modulators of hepatocyte growth factor/scatter factor activities | HGF, HDGF, MET | ALDH1A1 510/4885MAPT 4612/4885GAA 2947/4885 |
| US-20100256117-A1 | HEPATOCYTE GROWTH FACTOR PATHWAY ACTIVATORS IN FIBROTIC CONNECTIVE TISSUE DISEASES | HGF, HDGF, HGFAC | ALDH1A1 1992/4885MAPT 4274/4885GAA 3118/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.