Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B known ✓ | P49841 | 1/20 | 0.30 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
| ▸ | PAK4 | O96013 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.30 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31224952 | 0.87 | MKNK1 (0.43) | ROCK2MKNK1MKNK2 | |
| SCHEMBL31225030 | 0.83 | CYP11B2 (0.47) | MTOR | |
| Lithium Ion SCHEMBL31224930 | 0.79 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL31224823 | 0.74 | MAP2K4 (0.47) | MTORROCK2 | |
| SCHEMBL31224868 | 0.72 | LDHA (0.41) | ROCK2 | |
| SCHEMBL31224620 | 0.70 | GABRG2 (0.48) | MTOR | |
| SCHEMBL31224674 | 0.69 | MTOR (0.42) | MTOR | |
| SCHEMBL31224724 | 0.68 | ROCK2 (0.42) | ROCK2 | |
| SCHEMBL31224632 | 0.68 | ATAD2 (0.43) | — | |
| SCHEMBL11086663 | 0.67 | RAB9A (0.43) | GSK3BMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676926-A1 | BICYCLIC HETEROARYL COMPOUNDS FOR USE AS GPR35 MODULATORS | ThirtyFiveBio Limited (GB) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024184650-A1 | BICYCLIC HETEROARYL COMPOUNDS FOR USE AS GPR35 MODULATORS. | ThirtyFiveBio Limited (GB) | 2024-09-12 | — | — | WO | disclosed |