Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.50 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.50 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.46 |
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL1929109 | 1.00 | HPGD (0.50) | HPGDNPC1RAB9ALMNATDP1 | |
| SCHEMBL3294988 | 0.97 | LMNA (0.53) | HPGDNPC1RAB9ALMNATDP1 | |
| SCHEMBL29688196 | 0.97 | LMNA (0.53) | HPGDNPC1RAB9ALMNATDP1 | |
| SCHEMBL28097482 | 0.95 | HPRT1 (0.53) | HPGDNPC1RAB9ALMNATDP1 | |
| Hydrogen Sulfide SCHEMBL27592528 | 0.95 | NPC1 (0.50) | HPGDNPC1RAB9ALMNATDP1 | |
| SCHEMBL9876442 | 0.92 | ACHE (0.53) | HPGDNPC1RAB9ALMNATDP1 | |
| SCHEMBL8036362 | 0.92 | LMNA (0.50) | HPGDNPC1RAB9ALMNATDP1 | |
| Hydrogen Sulfide SCHEMBL28059715 | 0.86 | NPC1 (0.44) | HPGDNPC1RAB9ALMNATDP1 | |
| Water SCHEMBL11019701 | 0.86 | ACHE (0.59) | HPGDNPC1RAB9ALMNATDP1 | |
| SCHEMBL24279376 | 0.84 | HPGD (0.68) | HPGDNPC1RAB9ALMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 150 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4022391-A2 | HEAT SENSITIVE RECORDING MATERIAL WITH NON-PHENOLIC COLOR DEVELOPERS | Solenis Technologies Cayman, L.P. (KY) | 2022-07-06 | — | — | EP | claimed |
| WO-2021041600-A2 | HEAT SENSITIVE RECORDING MATERIAL WITH NON-PHENOLIC COLOR DEVELOPERS | SOLENIS TECHNOLOGIES CAYMAN, L.P. (KY) | 2021-03-04 | — | — | WO | claimed |
| US-20210060994-A1 | HEAT SENSITIVE RECORDING MATERIAL WITH NON-PHENOLIC COLOR DEVELOPERS | BASF SE (DE) | 2021-03-04 | — | — | US | claimed |
| EP-1140515-B1 | HEAT SENSITIVE RECORDING MATERIAL | CIBA SC HOLDING AG (CH) | 2004-09-15 | — | — | EP | claimed |
| US-6624117-B1 | Heat sensitive recording material | CIBA SPECIALTY CHEMICALS CORPORATION | 2003-09-23 | — | — | US | claimed |
| US-20030139293-A1 | Heat sensitive recording material | CIBA SPECIALTY CHEMICALS CORP. | 2003-07-24 | — | — | US | claimed |
| EP-1268215-A1 | HEAT SENSITIVE RECORDING MATERIAL | Ciba SC Holding AG (CH) | 2003-01-02 | — | — | EP | claimed |
| WO-2001072527-A1 | HEAT SENSITIVE RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2001-10-04 | — | — | WO | claimed |
| WO-2024143345-A1 | HEAT-SENSITIVE RECORDING BODY | 王子ホールディングス株式会社 | 2024-07-04 | — | — | WO | disclosed |
| WO-2024128254-A1 | HEAT-SENSITIVE RECORDING BODY | 王子ホールディングス株式会社 | 2024-06-20 | — | — | WO | disclosed |
| US-11993095-B2 | Heat-sensitive recording material | Oji Holdings Corporation (JP) | 2024-05-28 | — | — | US | disclosed |
| US-20240140124-A1 | HEAT-SENSITIVE RECORDING MATERIAL AND METHOD OF MANUFACTURING THE SAME | OJI HOLDING CORPORATION (JP) | 2024-05-02 | — | — | US | disclosed |
| US-20230391126-A1 | HEAT-SENSITIVE RECORDING BODY | Oji Holdings Corporation (JP) | 2023-12-07 | — | — | US | disclosed |
| EP-4234260-A1 | HEAT-SENSITIVE RECORDING BODY | Oji Holdings Corporation (JP) | 2023-08-30 | — | — | EP | disclosed |
| EP-0679530-A1 | Heat-sensitive recording material containing polyethylene | NEW OJI PAPER CO., LTD. (JP) | 1995-11-02 | — | — | EP | disclosed |
| US-5443909-A | Heat sensitive recordin material; substrate, recording layer containing colorless basic dye and protective coatings | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1995-08-22 | — | — | US | disclosed |
| EP-0545442-B1 | Microcapsule containing ultraviolet absorber and heat sensitive recording material using the same | NEW OJI PAPER CO LTD (JP) | 1995-04-05 | — | — | EP | disclosed |
| US-5401708-A | Water soluble graft copolymer of unsaturated acid and a polysiloxane as a water resistant coating for thermal printing | KANZAKI PAPER MFG. CO., LTD. (JP) | 1995-03-28 | — | — | US | disclosed |
| US-5272127-A | Heat sensitive recording material using microcapsules containing ultraviolet absorber | KANZAKI PAPER MANUFACTURING CO., LTD. (JP) | 1993-12-21 | — | — | US | disclosed |
| EP-0545442-A1 | Microcapsule containing ultraviolet absorber and heat sensitive recording material using the same | NEW OJI PAPER CO., LTD. (JP) | 1993-06-09 | — | — | EP | disclosed |