SCHEMBL31339990

SCHEMBL31339990

Cc1cnc(NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc1-c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ SORT1 Q99523 1/20 0.50
▸ JUN P05412 1/20 0.49
▸ NFKB1 P19838 1/20 0.49
▸ NFKB2 Q00653 1/20 0.49
▸ RELA Q04206 1/20 0.49
▸ P2RX1 P51575 1/20 0.46
▸ TRPV1 Q8NER1 3/20 0.46
▸ LCK P06239 1/20 0.46
▸ BTK Q06187 1/20 0.46
▸ NTRK1 P04629 2/20 0.45
▸ MCHR1 Q99705 1/20 0.45
▸ TEK Q02763 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31339978 0.90 BTK (0.48) SORT1TRPV1LCKBTKMCHR1
SCHEMBL31340012 0.87 KDM4E (0.46) SORT1TRPV1LCKBTK
SCHEMBL31339954 0.86 VNN1 (0.45) SORT1TRPV1MCHR1
SCHEMBL31339994 0.85 TRPV1 (0.46) SORT1TRPV1LCKMCHR1TEK
SCHEMBL31339981 0.85 ALDH1A1 (0.43) SORT1P2RX1TRPV1MCHR1
SCHEMBL31339987 0.84 TRPV1 (0.57) TRPV1TEK
SCHEMBL31340005 0.83 TRPV1 (0.46) TRPV1
SCHEMBL31339962 0.83 LCK (0.59) TRPV1LCKBTKTEK
SCHEMBL34462417 0.82 TRPV1 (0.47) TRPV1
SCHEMBL31340007 0.81 PTGS1 (0.54) SORT1TRPV1BTK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF JILIN UNIVERSITY (CN) 2026-05-07 — — US disclosed
EP-4725485-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF Jilin University (CN) 2026-04-15 — — EP disclosed
CN-119285557-A CD97 and GSDME interaction inhibitor with anti-tumor activity and application thereof 吉林大学 2025-01-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF GZMB, CD74, GSDMD SORT1 4391/4885JUN 2756/4885NFKB1 2188/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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