SCHEMBL31339987

SCHEMBL31339987

Cc1cnc(NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc1-c1ccc(NC(=O)c2cccnc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 4/20 0.57
▸ CSF1R P07333 3/20 0.55
▸ BRAF P15056 2/20 0.55
▸ MEN1 O00255 1/20 0.52
▸ TSHR P16473 1/20 0.52
▸ KMT2A Q03164 1/20 0.52
▸ TRPA1 O75762 1/20 0.51
▸ TEK Q02763 1/20 0.49
▸ RAB9A P51151 2/20 0.49
▸ MAPT P10636 2/20 0.49
▸ LMNA P02545 1/20 0.49
▸ TP53 P04637 1/20 0.49
▸ KDM4E B2RXH2 1/20 0.48
▸ NPC1 O15118 1/20 0.48
▸ GAA P10253 1/20 0.48
▸ SMN1; SMN2 Q16637 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ KDR P35968 1/20 0.48
▸ PIKFYVE Q9Y2I7 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31339990 0.84 SORT1 (0.50) TRPV1TEK
SCHEMBL31339978 0.83 BTK (0.48) TRPV1
SCHEMBL31339994 0.83 TRPV1 (0.46) TRPV1TEKKDR
SCHEMBL31340005 0.82 TRPV1 (0.46) TRPV1
SCHEMBL31340012 0.81 KDM4E (0.46) TRPV1MEN1TSHRKMT2AMAPT
SCHEMBL34462417 0.80 TRPV1 (0.47) TRPV1MAPTLMNATP53
SCHEMBL31339954 0.80 VNN1 (0.45) TRPV1MAPTKDM4E
SCHEMBL31339981 0.79 ALDH1A1 (0.43) TRPV1MEN1KMT2AMAPTLMNA
SCHEMBL31339962 0.79 LCK (0.59) TRPV1CSF1RTEKGAAKDR
SCHEMBL31340007 0.75 PTGS1 (0.54) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF JILIN UNIVERSITY (CN) 2026-05-07 — — US disclosed
EP-4725485-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF Jilin University (CN) 2026-04-15 — — EP disclosed
CN-119285557-A CD97 and GSDME interaction inhibitor with anti-tumor activity and application thereof 吉林大学 2025-01-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF GZMB, CD74, GSDMD TRPV1 1150/4885CSF1R 2297/4885BRAF 420/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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