SCHEMBL31339994

SCHEMBL31339994

Cc1cnc(NC(=O)c2cc(C(F)(F)F)cc(C(F)(F)F)c2)nc1-c1ccc(NC=O)cc1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 3/20 0.46
▸ SORT1 Q99523 1/20 0.43
▸ MCHR1 Q99705 1/20 0.43
▸ LCK P06239 2/20 0.43
▸ KDR P35968 2/20 0.43
▸ JAK3 P52333 2/20 0.43
▸ MAPK14 Q16539 2/20 0.43
▸ HDAC3 O15379 1/20 0.41
▸ HDAC8 Q9BY41 1/20 0.41
▸ HDAC6 Q9UBN7 1/20 0.41
▸ TEK Q02763 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31339978 0.86 BTK (0.48) TRPV1SORT1MCHR1LCK
SCHEMBL31339990 0.85 SORT1 (0.50) TRPV1SORT1MCHR1LCKTEK
SCHEMBL31339954 0.85 VNN1 (0.45) TRPV1SORT1MCHR1
SCHEMBL31340012 0.84 KDM4E (0.46) TRPV1SORT1LCK
SCHEMBL31340005 0.83 TRPV1 (0.46) TRPV1HDAC3HDAC8HDAC6
SCHEMBL31339987 0.83 TRPV1 (0.57) TRPV1KDRTEK
SCHEMBL31339981 0.82 ALDH1A1 (0.43) TRPV1SORT1MCHR1
SCHEMBL34462417 0.79 TRPV1 (0.47) TRPV1
SCHEMBL31340007 0.78 PTGS1 (0.54) TRPV1SORT1
SCHEMBL31339962 0.78 LCK (0.59) TRPV1LCKKDRJAK3MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF JILIN UNIVERSITY (CN) 2026-05-07 — — US disclosed
EP-4725485-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF Jilin University (CN) 2026-04-15 — — EP disclosed
CN-119285557-A CD97 and GSDME interaction inhibitor with anti-tumor activity and application thereof 吉林大学 2025-01-10 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF GZMB, CD74, GSDMD TRPV1 1150/4885SORT1 4391/4885MCHR1 4876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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