SCHEMBL34462417

SCHEMBL34462417

Cc1ccccc1CCC(=O)Nc1ccc(-c2nc(NC(=O)c3cc(C(F)(F)F)cc(C(F)(F)F)c3)ncc2C)cc1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ TRPV1 Q8NER1 3/20 0.47
▸ NOTUM Q6P988 1/20 0.43
▸ RHOC P08134 2/20 0.42
▸ RHOA P61586 2/20 0.42
▸ CETP P11597 1/20 0.41
▸ LMNA P02545 1/20 0.41
▸ TP53 P04637 1/20 0.41
▸ MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL34462408 0.87 TRPV1 (0.45) TRPV1RHOCRHOA
SCHEMBL31340005 0.84 TRPV1 (0.46) TRPV1RHOCRHOA
SCHEMBL31339990 0.82 SORT1 (0.50) TRPV1
SCHEMBL31339987 0.80 TRPV1 (0.57) TRPV1LMNATP53MAPT
SCHEMBL31339978 0.80 BTK (0.48) TRPV1
SCHEMBL31339994 0.79 TRPV1 (0.46) TRPV1
SCHEMBL31340012 0.77 KDM4E (0.46) TRPV1MAPT
SCHEMBL31339954 0.76 VNN1 (0.45) TRPV1MAPT
SCHEMBL31339981 0.76 ALDH1A1 (0.43) TRPV1LMNAMAPT
SCHEMBL31339962 0.73 LCK (0.59) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF JILIN UNIVERSITY (CN) 2026-05-07 — — US disclosed
EP-4725485-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF Jilin University (CN) 2026-04-15 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124202-A1 CD97 AND GSDME INTERACTION INHIBITOR HAVING ANTI-TUMOR ACTIVITY AND APPLICATION THEREOF GZMB, CD74, GSDMD TRPV1 1150/4885NOTUM 4311/4885RHOC 4775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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