Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.43 |
| ▸ | P2RX2 | Q9UBL9 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5800387 | 0.79 | HTR1A (0.56) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL12205020 | 0.76 | P2RX3 (0.53) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL5693440 | 0.75 | HTR1A (0.51) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| Hydrochloric Acid SCHEMBL30586342 | 0.74 | PMP22 (0.53) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL8125001 | 0.74 | ADRA2A (0.46) | HTR2AHTR2CHTR2BCYP2D6TSHR | |
| SCHEMBL12462185 | 0.73 | HTR1A (0.43) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL16918802 | 0.73 | HTR1A (0.43) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL27229037 | 0.73 | HTR1A (0.44) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL481337 | 0.73 | HTR2A (0.54) | HTR1AHTR2AHTR2CHTR2BCYP1A2 | |
| SCHEMBL27534912 | 0.72 | HTR1A (0.45) | HTR1AHTR2AHTR2CHTR2BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160411-A1 | BENZOXATHIINE AND BENZOXATHIOLE DERIVATIVES AND USES THEREOF | WYETH (US) | 2010-06-24 | — | — | US | disclosed |
| US-7728155-B2 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents | WYETH LLC (US) | 2010-06-01 | — | — | US | disclosed |
| US-7687620-B2 | [1,4]diazepino[6,7,1-IJ]quinoline derivatives as antipsychotic and antiobesity agents | WYETH LLC (US) | 2010-03-30 | — | — | US | disclosed |
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | WYETH | 2010-02-11 | — | — | US | disclosed |
| US-7608626-B2 | Substituted indolizines and derivatives as CNS agents | WYETH (US) | 2009-10-27 | — | — | US | disclosed |
| US-20090082434-A1 | Dihydrobenzofuranyl Alkanamine Derivatives and Methods for Using Same | WYETH (US) | 2009-03-26 | — | — | US | disclosed |
| US-7435837-B2 | Dihydrobenzofuranyl alkanamine derivatives and methods for using same | WYETH (US) | 2008-10-14 | — | — | US | disclosed |
| US-20080200541-A1 | Benzofuranyl Alkanamine Derivatives and Uses Thereof | WYETH (US) | 2008-08-21 | — | — | US | disclosed |
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | WYETH (US) | 2008-07-31 | — | — | US | disclosed |
| US-7402687-B2 | Dihydrobenzofuran derivatives and uses thereof | WYETH (US) | 2008-07-22 | — | — | US | disclosed |
| US-20050124692-A1 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents | WYETH (US) | 2005-06-09 | — | — | US | disclosed |
| EP-1497296-A1 | 1,4 DIAZOCINO 7,8,1-hi INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1497293-A1 | (1,4)DIAZEPINO(6,7,1-IJ)QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| EP-1497294-A1 | 1,2,3,4,7,8-HEXAHYDRO-6 i H /i - 1,4 DIAZEPINO 6,7 ,1- i 1J /i QUINOLINE DERIVATIVES AS ANTIPSYCHOTIC AND ANTI OBESITY AGENTS | Wyeth (US) | 2005-01-19 | — | — | EP | disclosed |
| US-20040034005-A1 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | WYETH | 2004-02-19 | — | — | US | disclosed |
| US-20040019040-A1 | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH | 2004-01-29 | — | — | US | disclosed |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | WYETH | 2004-01-15 | — | — | US | disclosed |
| WO-2003091257-A1 | [1,4]DIAZOCINO [7,8,1-hi]INDOLE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
| WO-2003091251-A1 | 1,2,3,4,7,8-HEXAHYDRO-6H-[1,4]DIAZEPINO[6,7,1-1J]QUINOLINE DERIVATIVES AS ANTIPSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
| WO-2003091250-A1 | [1,4]DIAZEPINO[6,7,1-IJ]QUINOLINE DERIVATIVES AS ANTI PSYCHOTIC AND ANTIOBESITY AGENTS | WYETH (US) | 2003-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160411-A1 | BENZOXATHIINE AND BENZOXATHIOLE DERIVATIVES AND USES THEREOF | HTR2C, HTR3B, HTR1A | HTR1A 3/4885HTR2A 6/4885HTR2C 1/4885 |
| US-20080182891-A1 | CHROMANE AND CHROMENE DERIVATIVES AND USES THEREOF | HTR1A, HTR2C, CHRM1 | HTR1A 1/4885HTR2A 12/4885HTR2C 2/4885 |
| US-20050124692-A1 | Dihydrobenzofuranyl alkanamines and methods for using same as cns agents | HTR2C, HTR1A, HTR1B | HTR1A 2/4885HTR2A 12/4885HTR2C 1/4885 |
| US-20040019040-A1 | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR7 | HTR1A 2/4885HTR2A 6/4885HTR2C 1/4885 |
| US-20090082434-A1 | Dihydrobenzofuranyl Alkanamine Derivatives and Methods for Using Same | HTR2C, HTR1A, HTR3A | HTR1A 2/4885HTR2A 11/4885HTR2C 1/4885 |
| US-20100035871-A1 | BENZOXAZINE DERIVATIVES AND USES THEREOF | HTR2C, HTR5A, NPY1R | HTR1A 4/4885HTR2A 5/4885HTR2C 1/4885 |
| US-20040009970-A1 | [1,4]Diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | HTR2C, HTR1A, HTR1D | HTR1A 2/4885HTR2A 6/4885HTR2C 1/4885 |
| US-20080200541-A1 | Benzofuranyl Alkanamine Derivatives and Uses Thereof | HTR2C, HTR1A, HTR3A | HTR1A 2/4885HTR2A 4/4885HTR2C 1/4885 |
| US-20040034005-A1 | [1,4]Diazocino[7,8,1-hi]indole derivatives as antipsychotic and antiobesity agents | HTR1A, HTR2C, HTR1D | HTR1A 1/4885HTR2A 9/4885HTR2C 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.