Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of 7-Hydroxyflavone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 known ✓ | P09874 | 4/20 | 0.78 |
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.78 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.68 |
| ▸ | ALOX5 known ✓ | P09917 | 1/20 | 0.67 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.66 |
| ▸ | DPP4 known ✓ | P27487 | 1/20 | 0.66 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.97 |
| ▸ | MAOB | P27338 | 3/20 | 0.97 |
| ▸ | MAOA | P21397 | 2/20 | 0.97 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.97 |
| ▸ | PKM | P14618 | 2/20 | 0.97 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.97 |
| ▸ | CA12 | O43570 | 2/20 | 0.97 |
| ▸ | CA1 | P00915 | 2/20 | 0.97 |
| ▸ | CA2 | P00918 | 2/20 | 0.97 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.97 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.97 |
| ▸ | CA9 | Q16790 | 2/20 | 0.97 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 7-Hydroxyflavone SCHEMBL29678183 | 0.98 | CYP19A1 (1.00) | CYP19A1MAOBMAOACALM1PKM | |
| 7-Hydroxyflavone SCHEMBL312148 | 0.98 | CYP19A1 (1.00) | CYP19A1MAOBMAOACALM1PKM | |
| 7-Hydroxyflavone SCHEMBL10808394 | 0.97 | CYP19A1 (0.97) | CYP19A1MAOBMAOACALM1PKM | |
| 7-Hydroxyflavone SCHEMBL31035954 | 0.93 | CYP19A1 (0.89) | CYP19A1MAOBMAOACALM1PKM | |
| 7-Hydroxyflavone SCHEMBL27889515 | 0.93 | CYP19A1 (0.89) | CYP19A1MAOBMAOACALM1PKM | |
| Flavone SCHEMBL3515129 | 0.91 | CYP19A1 (0.86) | CYP19A1MAOBMAOACALM1PKM | |
| SCHEMBL157723 | 0.89 | CYP3A4 (1.00) | CYP19A1MAOBMAOACALM1PKM | |
| SCHEMBL31167385 | 0.89 | CYP3A4 (1.00) | CYP19A1MAOBMAOACALM1PKM | |
| SCHEMBL31675776 | 0.88 | CYP3A4 (1.00) | CYP19A1MAOBMAOACALM1PKM | |
| SCHEMBL3135989 | 0.88 | CYP3A4 (1.00) | CYP19A1MAOBMAOACALM1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109971869-A | The detection method and kit of Nitrobacter bacterium | 浦江县美泽生物科技有限公司 | 2019-07-05 | — | — | CN | claimed |
| CN-109890376-A | Composition is used in PGC-1 α activation | 三得利控股株式会社 | 2019-06-14 | — | — | CN | claimed |
| CN-108660809-A | A kind of color fixing agent improving silk knitwear dyeability | 阜南美凯服饰有限公司 | 2018-10-16 | — | — | CN | claimed |
| CN-109971869-A | The detection method and kit of Nitrobacter bacterium | 浦江县美泽生物科技有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109971869-A | The detection method and kit of Nitrobacter bacterium | 浦江县美泽生物科技有限公司 | 2019-07-05 | — | — | CN | disclosed |
| CN-109938350-A | A kind of myrica ruba marc alcohol extract and preparation method with effect of lowering blood sugar | 浙江省农业科学院 | 2019-06-28 | — | — | CN | disclosed |
| CN-109890376-A | Composition is used in PGC-1 α activation | 三得利控股株式会社 | 2019-06-14 | — | — | CN | disclosed |
| CN-108660809-A | A kind of color fixing agent improving silk knitwear dyeability | 阜南美凯服饰有限公司 | 2018-10-16 | — | — | CN | disclosed |
| CN-101613334-B | Flavonoid derivative and medical application thereof | INST PHARM & TOXICOLOGY AMMS | 2012-07-04 | — | — | CN | disclosed |
| CN-101613334-A | Flavone derivative and medicinal use thereof | INST PHARM & TOXICOLOGY AMMS | 2009-12-30 | — | — | CN | disclosed |