Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | NEK2 | P51955 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | APAF1 | O14727 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CASP6 | P55212 | 1/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.48 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770512 | 0.88 | ALDH1A1 (0.67) | ALDH1A1CD274CHEK1NEK2KDM4E | |
| SCHEMBL3139236 | 0.86 | CHEK1 (0.51) | CD274CHEK1KDM4ETNFRSF1AABCB1 | |
| SCHEMBL3133634 | 0.85 | ALDH1A1 (0.56) | ALDH1A1CD274CHEK1NEK2KDM4E | |
| SCHEMBL17177740 | 0.84 | ALDH1A1 (0.62) | ALDH1A1CD274CHEK1NEK2KDM4E | |
| SCHEMBL29936484 | 0.84 | CD274 (0.48) | ALDH1A1CD274CHEK1NEK2KDM4E | |
| SCHEMBL10459347 | 0.83 | ALDH1A1 (0.61) | ALDH1A1CHEK1NEK2KDM4EAPAF1 | |
| SCHEMBL1921213 | 0.82 | ALDH1A1 (0.56) | ALDH1A1CHEK1NEK2KDM4EAPAF1 | |
| SCHEMBL21561215 | 0.82 | LMNA (0.60) | ALDH1A1KDM4EAPAF1RECQLCASP6 | |
| SCHEMBL3135536 | 0.82 | CTSD (0.53) | CD274TNFRSF1AHTTABCB1NPC1 | |
| SCHEMBL504872 | 0.81 | CHEK1 (0.60) | ALDH1A1CHEK1KDM4EAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-2119719-A1 | THIAZEPINE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2009-11-18 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100004221-A1 | THIAZEPINE DERIVATIVE | HSD11B1, HSD17B1, HSD3B1 | ALDH1A1 28/4885CD274 4744/4885CHEK1 1983/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.