Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 5/20 | 0.33 |
| ▸ | HTR2C known ✓ | P28335 | 3/20 | 0.32 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.32 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.32 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 2/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.32 |
| ▸ | HTR1B | P28222 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | HTR7 | P34969 | 2/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.32 |
| ▸ | HTR5A | P47898 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL31411451 | 0.90 | HTR7 (0.41) | HTR2AHTR2CHTR1AADRA2AADRA2B | |
| SCHEMBL31411322 | 0.89 | HTR2A (0.39) | HTR2AHTR2CHTR7HTR2BHTR6 | |
| Fumaric Acid SCHEMBL31411316 | 0.79 | ACHE (0.35) | ALDH1A1KDM4E | |
| SCHEMBL31411335 | 0.78 | HTR2B (0.38) | HTR2AHTR2CHTR1AADRA2AADRA2B | |
| Fumaric Acid SCHEMBL31651549 | 0.77 | ALDH1A1 (0.36) | HTR2AALDH1A1 | |
| Fumaric Acid SCHEMBL31411428 | 0.76 | WNT1 (0.41) | HTR2AHTR2CHTR1AHTR2BWNT1 | |
| Fumaric Acid SCHEMBL31411382 | 0.76 | HTR2C (0.46) | HTR2AHTR2CHTR1AADRA2AADRA2B | |
| Fumaric Acid SCHEMBL31411475 | 0.76 | HTR2A (0.41) | HTR2AHTR2CHTR1AADRA2AADRA2B | |
| SCHEMBL31411299 | 0.75 | HTR1A (0.46) | HTR2AHTR2CHTR1AHTR7HTR6 | |
| SCHEMBL31411359 | 0.75 | HTR2A (0.36) | HTR2AHTR2CHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4735425-A1 | COMPOUNDS | Psylo Pty Ltd (AU) | 2026-05-06 | — | — | EP | disclosed |
| US-20250353818-A1 | Compounds | Psylo Pty Ltd (AU) | 2025-11-20 | — | — | US | disclosed |
| US-12428380-B2 | Compounds | Psylo Pty Ltd (AU) | 2025-09-30 | — | — | US | disclosed |
| US-20250214943-A1 | Compounds | Psylo Pty Ltd (AU) | 2025-07-03 | — | — | US | disclosed |
| WO-2025000053-A1 | COMPOUNDS | Psylo Pty Ltd (AU) | 2025-01-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250214943-A1 | Compounds | NLN, SLC18A2, PYGB | HTR2A 94/4885HTR2C 23/4885HRH1 2945/4885 |
| US-12428380-B2 | Compounds | NLN, SLC18A2, PYGB | HTR2A 94/4885HTR2C 23/4885HRH1 2945/4885 |
| US-20250353818-A1 | Compounds | NLN, SLC18A2, PYGB | HTR2A 94/4885HTR2C 23/4885HRH1 2945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.