Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13356460 | 0.84 | MEN1 (0.39) | MEN1KMT2AMAPTL3MBTL1NPSR1 | |
| SCHEMBL2929425 | 0.84 | MAPT (0.32) | MAPTL3MBTL1NPSR1ALDH1A1LMNA | |
| SCHEMBL27622210 | 0.84 | MAPT (0.39) | MEN1KMT2AMAPTL3MBTL1NPSR1 | |
| SCHEMBL14401659 | 0.84 | HTT (0.37) | MEN1KMT2AMAPTL3MBTL1NPSR1 | |
| SCHEMBL3141869 | 0.80 | HTT (0.33) | MAPTL3MBTL1NPSR1ALDH1A1LMNA | |
| SCHEMBL2925238 | 0.79 | CNR1 (0.35) | MEN1KMT2AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL13356459 | 0.76 | CNR1 (0.34) | MEN1KMT2AL3MBTL1ALDH1A1LMNA | |
| SCHEMBL6068973 | 0.75 | ALDH1A1 (0.30) | MAPTALDH1A1 | |
| SCHEMBL2929120 | 0.73 | HTT (0.36) | MEN1KMT2AALDH1A1LMNAMAPK1 | |
| SCHEMBL4193744 | 0.72 | ALDH1A1 (0.37) | MEN1KMT2AMAPTALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1733713-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone dervative, a coupling agent and a selected surface-active agent | OREAL (FR) | 2010-06-02 | — | — | EP | disclosed |
| EP-1733713-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone dervative, a coupling agent and a selected surface-active agent | OREAL (FR) | 2010-06-02 | — | — | EP | disclosed |
| EP-1733716-B1 | Composition for dyeing keratin fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and an associative polyurethane polymer | OREAL (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1733714-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a polyol | OREAL (FR) | 2010-05-19 | — | — | EP | disclosed |
| EP-1733715-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a heterocyclic direct dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1728500-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1733715-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a heterocyclic direct dye | OREAL (FR) | 2010-01-27 | — | — | EP | disclosed |
| EP-1728499-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative and a 2,3-diaminopyridine coupler | OREAL (FR) | 2010-01-06 | — | — | EP | disclosed |
| EP-1728499-B1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative and a 2,3-diaminopyridine coupler | OREAL (FR) | 2010-01-06 | — | — | EP | disclosed |
| US-7642360-B2 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2010-01-05 | — | — | US | disclosed |
| EP-1733713-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone dervative, a coupling agent and a selected surface-active agent | L'OREAL (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1733714-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a polyol | L'OREAL (FR) | 2006-12-20 | — | — | EP | disclosed |
| EP-1733715-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative, a coupling agent and a heterocyclic direct dye | L'OREAL (FR) | 2006-12-20 | — | — | EP | disclosed |
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | L'OREAL S.A. (FR) | 2006-12-14 | — | — | US | disclosed |
| EP-1728500-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolon derivative and a cationic oxidation dye | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| EP-1728499-A1 | Composition for dyeing keratinic fibres comprising a diamino-N,N-dihydro-pyrazolone derivative and a 2,3-diaminopyridine coupler | L'OREAL (FR) | 2006-12-06 | — | — | EP | disclosed |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | L'OREAL S.A. (FR) | 2005-08-04 | — | — | US | disclosed |
| EP-1550656-A1 | 4-5-diamino-n,n-dihydro-pyrazol-3-one derivatives for use in composition for dyeing keratin fibres | L'OREAL (FR) | 2005-07-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060277691-A1 | Composition for dyeing keratin fibers, comprising a diamino-N,N-dihydropyrazolone compound, a coupler, and a polyol | KRT18, C9, NDUFA10 | MEN1 2580/4885KMT2A 2291/4885MAPT 1357/4885 |
| US-20060277692-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler, and at least one surfactant | KRT18, DSP, DSG1 | MEN1 3903/4885KMT2A 2918/4885MAPT 1979/4885 |
| US-20050166335-A1 | Composition for dyeing keratinous fibers comprising at least one diamino-N,N-dihydropyrazolone derivative | KRT18, DAO, AOC1 | MEN1 3832/4885KMT2A 2286/4885MAPT 634/4885 |
| US-20060277693-A1 | Composition for dyeing keratin fibers, comprising at least one diamino-N,N-dihydropyrazolone derivative, at least one coupler and at least one associative polyurethane polymer | KRT18, PRKDC, DSP | MEN1 3304/4885KMT2A 1211/4885MAPT 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.