SCHEMBL31454232

SCHEMBL31454232

COC(=O)c1c(-c2ccccc2)ccn1-c1cccc(OC)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 1/20 0.41
SRC P12931 1/20 0.41
FGFR2 P21802 1/20 0.41
FGFR4 P22455 1/20 0.41
FGFR3 P22607 1/20 0.41
GABRA1 P14867 2/20 0.38
GABRG2 P18507 2/20 0.38
GABRB3 P28472 2/20 0.38
GABRA3 P34903 2/20 0.38
FABP4 P15090 1/20 0.37
TUBB4A P04350 1/20 0.37
TUBB P07437 1/20 0.37
TUBA3C P0DPH7 1/20 0.37
TUBA1B P68363 1/20 0.37
TUBA4A P68366 1/20 0.37
TUBB4B P68371 1/20 0.37
TUBB3 Q13509 1/20 0.37
TUBB2A Q13885 1/20 0.37
TUBB8 Q3ZCM7 1/20 0.37
TUBA3E Q6PEY2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31454199 0.83 JAK2 (0.38) ALDH1A1KDM4ELMNAMAPTKMT2A
SCHEMBL6560894 0.72 LMNA (0.44) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL31189437 0.70 FGFR1 (0.45) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL4137972 0.70 HTR7 (0.46) GABRA1GABRG2GABRB3GABRA3ALDH1A1
SCHEMBL16007133 0.69 ALDH1A1 (0.47) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL31454201 0.69 HTT (0.44) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL16056968 0.69 HTT (0.44) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL31019062 0.69 FGFR1 (0.57) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL24390319 0.68 AMY1A (0.50) FGFR1SRCFGFR2FGFR4FGFR3
SCHEMBL29915706 0.68 AMY1A (0.50) FGFR1SRCFGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119365460-A Compounds that interact with Ras superfamily proteins for the treatment of cancer, inflammatory diseases, RAS diseases, and fibrotic diseases 尚医治疗有限责任公司 2025-01-24 CN disclosed