Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA3 | P07451 | 1/20 | 0.33 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513227 | 0.74 | THRB (0.37) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL4513230 | 0.74 | THRB (0.37) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL31337844 | 0.59 | HCAR2 (0.39) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL12795430 | 0.59 | SMN1; SMN2 (0.41) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL21989264 | 0.58 | APEX1 (0.37) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10378479 | 0.56 | — | — | |
| SCHEMBL183861 | 0.56 | HCAR2 (0.39) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6852630 | 0.56 | ABCG2 (0.57) | THRBATMKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL6852555 | 0.56 | NFE2L2 (0.69) | KDM4EALDH1A1SMN1; SMN2HPGDHSD17B10 | |
| SCHEMBL6852627 | 0.56 | ABCG2 (0.57) | THRBATMKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GLIAMED, INC. (US) | 2010-06-10 | — | — | US | disclosed |
| EP-1433781-B1 | Pyrrolidine carboxylic acid derivatives | MGI GP INC (US) | 2010-02-24 | — | — | EP | disclosed |
| US-7652060-B2 | Neurotrophic N-glyoxyl-prolyl ester compounds e.g. 3-phenyl-1-propyl (2S)-1-(3,3-dimethyl-1,2-dioxopentyl)-2-pyrrolidinecarboxylate; non-immunosuppressive; side effect reduction; neurodegenerative diseases | Glia Med, Inc (US) | 2010-01-26 | — | — | US | disclosed |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | HAMILTON GREGORY S | 2008-03-27 | — | — | US | disclosed |
| US-7282510-B2 | Small molecule inhibitors of rotamase enzyme activity | GLIAMED, INC. (US) | 2007-10-16 | — | — | US | disclosed |
| EP-1479373-B1 | Hair growth compositions and uses | GUILFORD PHARM INC (US) | 2007-01-10 | — | — | EP | disclosed |
| US-7056935-B2 | Rotamase enzyme activity inhibitors | GPI NIL HOLDINGS, INC. (US) | 2006-06-06 | — | — | US | disclosed |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD NIL HOLDINGS, INC. | 2005-12-08 | — | — | US | disclosed |
| US-6943187-B2 | Pyrrolidine derivative hair growth compositions and uses | GPI NIL HOLDINGS, INC. (US) | 2005-09-13 | — | — | US | disclosed |
| EP-1479373-A1 | Hair growth compositions and uses | GPI NIL Holdings, Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| EP-0992492-A1 | Small molecule inhibitors of rotamase enzyme activity | GUILFORD PHARMACEUTICALS INC. (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-2000016603-A2 | BRIDGED HETEROCYCLIC DERIVATIVES | GPI NIL HOLDINGS, INC. (US) | 2000-03-30 | — | — | WO | disclosed |
| WO-2000009124-A1 | PYRROLIDINE DERIVATIVES FOR VISION AND MEMORY DISORDERS | GPI NIL HOLDINGS, INC. (US) | 2000-02-24 | — | — | WO | disclosed |
| US-5859031-A | Small molecule inhibitors of rotamase enzyme activity | GPI NIL HOLDINGS, INC. (US) | 1999-01-12 | — | — | US | disclosed |
| US-5795908-A | FKBP IMMUNOPHILINS FOR ENZYME INHIBITORS | GPI NIL HOLDINGS, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| EP-0769006-A4 | — | GUILFORD PHARM INC (US) | 1997-05-28 | — | — | EP | disclosed |
| EP-0769006-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5614547-A | Small molecule inhibitors of rotamase enzyme | GUILFORD PHARMACEUTICALS INC. (US) | 1997-03-25 | — | — | US | disclosed |
| WO-1996040633-A9 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | — | 1997-02-27 | — | — | WO | disclosed |
| WO-1996040633-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | GUILFORD PHARMACEUTICALS INC. (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100145071-A1 | SMALL MOLECULE INHIBITORS OF ROTAMASE ENZYME ACTIVITY | FKBP8, FKBP1A, FKBP2 | THRB 3872/4885ATM 4839/4885KDM4E 3513/4885 |
| US-20050272780-A1 | Small molecule inhibitors of rotamase enzyme activity | FKBP8, FKBP1A, PREP | THRB 3460/4885ATM 4792/4885KDM4E 3523/4885 |
| US-20080076817-A1 | Small Molecule Rotamase Enzyme Inhibitors | FKBP8, FKBP1A, FKBP2 | THRB 3821/4885ATM 4798/4885KDM4E 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.