Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18527599 | 0.93 | LMNA (0.32) | GAAHTTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL17203573 | 0.91 | MEN1 (0.31) | GAAMEN1KMT2AALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL1697483 | 0.80 | MAPT (0.34) | SMN1; SMN2ALDH1A1CYP1A2MAPTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3156602 | 0.78 | GABRA1 (0.40) | GAAHTTSMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL442699 | 0.76 | ALDH1A1 (0.32) | HTTSMN1; SMN2ALDH1A1POLBMAPT | |
| Hydrochloric Acid SCHEMBL3156599 | 0.75 | IDH1 (0.33) | SMN1; SMN2ALDH1A1HPGDKDM4EMAPT | |
| Hydrochloric Acid SCHEMBL3147260 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1HSD17B10CYP1A2CYP2D6 | |
| SCHEMBL442095 | 0.74 | ALDH1A1 (0.33) | HTTSMN1; SMN2ALDH1A1POLBMAPT | |
| Hydrochloric Acid SCHEMBL1609624 | 0.73 | — | — | |
| SCHEMBL18527602 | 0.73 | GABRA1 (0.37) | GAAHTTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12440831-B2 | Longer-lived ruthenium olefin metathesis catalysts supported by hemi-labile carbene ligands | The Trustees of the California State University (US) | 2025-10-14 | — | — | US | disclosed |
| US-20210138444-A1 | Longer-Lived Ruthenium Olefin Metathesis Catalysts Supported by Hemi-Labile Carbene Ligands | The California State University - Northridge (US) | 2021-05-13 | — | — | US | disclosed |
| EP-1582534-B1 | Olefin polymerization catalyst and polymerization process | ROHM & HAAS (US) | 2010-02-10 | — | — | EP | disclosed |
| US-7098278-B2 | Olefin polymerization catalyst and polymerization process | ROHM AND HAAS COMPANY (US) | 2006-08-29 | — | — | US | disclosed |
| US-20060128911-A1 | Olefin polymerization catalyst and polymerization process | GOODALL BRIAN L | 2006-06-15 | — | — | US | disclosed |
| US-7037987-B2 | Olefin polymerization catalyst and polymerization process | ROHN AND HAAS COMPANY (US) | 2006-05-02 | — | — | US | disclosed |
| EP-1582534-A1 | Olefin polymerization catalyst and polymerization process | ROHM AND HAAS COMPANY (US) | 2005-10-05 | — | — | EP | disclosed |
| US-20050215738-A1 | Olefin polymerization catalyst and polymerization process | ROHM AND HAAS COMPANY | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12440831-B2 | Longer-lived ruthenium olefin metathesis catalysts supported by hemi-labile carbene ligands | SQLE, MAX, MGLL | GAA 3031/4885HTT 941/4885SMN1; SMN2 1574/4885 |
| US-20210138444-A1 | Longer-Lived Ruthenium Olefin Metathesis Catalysts Supported by Hemi-Labile Carbene Ligands | SQLE, MAX, MGLL | GAA 3031/4885HTT 941/4885SMN1; SMN2 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.