Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.59 |
| ▸ | ACHE | P22303 | 8/20 | 0.53 |
| ▸ | BCHE | P06276 | 3/20 | 0.53 |
| ▸ | NQO1 | P15559 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13241089 | 0.85 | ACHE (0.50) | CYP2A6CYP1A2ACHEBCHENQO1 | |
| SCHEMBL8157352 | 0.84 | CYP1A2 (0.59) | CYP2A6CYP1A2ACHEBCHENQO1 | |
| SCHEMBL13241084 | 0.84 | ACHE (0.50) | CYP2A6CYP1A2ACHEBCHENQO1 | |
| SCHEMBL8393507 | 0.81 | NQO1 (0.67) | CYP2A6ACHEBCHENQO1ALDH1A1 | |
| SCHEMBL29919905 | 0.81 | NQO1 (0.67) | CYP2A6ACHEBCHENQO1ALDH1A1 | |
| SCHEMBL18053268 | 0.80 | CYP2A6 (0.50) | CYP2A6CYP1A2ACHEBCHEALDH1A1 | |
| SCHEMBL1402595 | 0.80 | NQO1 (0.50) | CYP2A6ACHEBCHENQO1ALDH1A1 | |
| SCHEMBL443625 | 0.80 | CYP1A2 (0.57) | CYP2A6CYP1A2ACHEBCHENQO1 | |
| SCHEMBL12804576 | 0.80 | ACHE (0.56) | CYP2A6CYP1A2ACHEBCHENQO1 | |
| SCHEMBL30088510 | 0.80 | CYP1A2 (0.57) | CYP2A6CYP1A2ACHEBCHENQO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11396505-B2 | Inhibitors of CaMKK2 and uses of same | NEW YORK UNIVERSITY (US) | 2022-07-26 | — | — | US | disclosed |
| US-20200369656-A1 | INHIBITORS OF CAMKK2 AND USES OF SAME | NEW YORK UNIVERSITY | 2020-11-26 | — | — | US | disclosed |
| US-10689381-B2 | Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance | THE SCRIPPS RESEARCH INSTITUTE (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190119277-A1 | VINBLASTINE 20' AMIDES: SYNTHETIC ANALOGS THAT MAINTAIN OR IMPROVE POTENCY AND SIMULTANEOUSLY OVERCOME Pgp-DERIVED EFFLUX AND RESISTANCE | THE SCRIPPS RESEARCH INSTITUTE | 2019-04-25 | — | — | US | disclosed |
| EP-1963399-B1 | POLYCYCLIC DIHYDROXY COMPOUNDS AND METHODS FOR PREPARATION | SABIC GLOBAL TECHNOLOGIES BV (NL) | 2016-07-27 | — | — | EP | disclosed |
| EP-1940771-B1 | POLYMERS, POLYMER COMPOSITIONS AND METHOD OF PREPARATION | SABIC INNOVATIVE PLASTICS IP (NL) | 2012-06-13 | — | — | EP | disclosed |
| EP-1846351-B1 | METHODS FOR PREPARING 1,1,1-TRIS(4-HYDROXYPHENYL)ALKANES | SABIC INNOVATIVE PLASTICS IP (NL) | 2010-03-03 | — | — | EP | disclosed |
| US-7425603-B2 | Polymers, polymer compositions, and method of preparation | GENERAL ELECTRIC COMPANY (US) | 2008-09-16 | — | — | US | disclosed |
| EP-1963399-A2 | CHROMANE SUBSTITUTED 2-ALKYL IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS ACID PUMP ANTAGONIST | General Electric Company (US) | 2008-09-03 | — | — | EP | disclosed |
| EP-1940771-A2 | POLYMERS, POLYMER COMPOSITIONS AND METHOD OF PREPARATION | General Electric Company (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007064569-A2 | CHROMANE SUBSTITUTED 2 -ALKYL IMIDAZOPYRIDINE DERIVATIVES AND USE THEREOF AS ACID PUMP ANTAGONISTS | GENERAL ELECTRIC COMPANY (US) | 2007-06-07 | — | — | WO | disclosed |
| US-20070123713-A1 | Polycyclic dihydroxy compound and methods for preparation | CITIBANK, N.A., AS COLLATERAL AGENT | 2007-05-31 | — | — | US | disclosed |
| US-20070123682-A1 | Polycarbonates, polyesters, polycarbonateesters, polyurethanes and epoxy resins prepared from monomers including N-4-[1,1'-di(p-hydroxyphenyl)ethyl]phenyl phthalimide or derivatives; articles with improved chemical resistance and high glass transition temperatures and refractive indices | SABIC GLOBAL TECHNOLOGIES IP B.V. (NL) | 2007-05-31 | — | — | US | disclosed |
| WO-2007053357-A2 | POLYMERS, POLYMER COMPOSITIONS AND METHOD OF PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070100156-A1 | POLYCYCLIC DIHYDROXY COMPOUNDS AND METHODS FOR PREPARATION | GENERAL ELECTRIC COMPANY (US) | 2007-05-03 | — | — | US | disclosed |
| US-7208620-B1 | Polycyclic dihydroxy compounds and methods for preparation | GENERAL ELECTRIC COMPANY (US) | 2007-04-24 | — | — | US | disclosed |
| WO-2006083745-A1 | METHODS FOR PREPARING 1,1,1-TRIS(4-HYDROXYPHENYL)ALKANES | GENERAL ELECTRIC COMPANY (US) | 2006-08-10 | — | — | WO | disclosed |
| US-20060173222-A1 | Reacting phenol and 2,4, pentanedione in the presence of an ion exchange resin catalyst and an optional mercaptan co-catalyst; polymerization of polycarbonates | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2006-08-03 | — | — | US | disclosed |
| WO-2006065570-A2 | PROCESS FOR PREPARING BISPHENOLS | GENERAL ELECTRIC COMPANY (US) | 2006-06-22 | — | — | WO | disclosed |
| US-20060135825-A1 | Process for preparing bisphenols | SHPP GLOBAL TECHNOLOGIES B.V. (NL) | 2006-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11396505-B2 | Inhibitors of CaMKK2 and uses of same | CAMKK2, CAMKK1, CAMK1 | CYP2A6 4059/4885CYP1A2 3639/4885ACHE 1869/4885 |
| US-20070100156-A1 | POLYCYCLIC DIHYDROXY COMPOUNDS AND METHODS FOR PREPARATION | PAH, CYP4A11, CYP4F11 | CYP2A6 342/4885CYP1A2 113/4885ACHE 1392/4885 |
| US-10689381-B2 | Vinblastine 20″ amides: synthetic analogs that maintain or improve potency and simultaneously overcome Pgp-derived efflux and resistance | ABCG2, ABCC1, GLS | CYP2A6 627/4885CYP1A2 852/4885ACHE 3403/4885 |
| US-20060135825-A1 | Process for preparing bisphenols | SSRP1, PCBP1, HPD | CYP2A6 23/4885CYP1A2 54/4885ACHE 1406/4885 |
| US-20070123713-A1 | Polycyclic dihydroxy compound and methods for preparation | PAH, DDT, CYP24A1 | CYP2A6 235/4885CYP1A2 169/4885ACHE 4060/4885 |
| US-20200369656-A1 | INHIBITORS OF CAMKK2 AND USES OF SAME | CAMKK2, CAMKK1, CAMK1 | CYP2A6 4059/4885CYP1A2 3639/4885ACHE 1869/4885 |
| US-20060173222-A1 | Reacting phenol and 2,4, pentanedione in the presence of an ion exchange resin catalyst and an optional mercaptan co-catalyst; polymerization of polycarbonates | HPD, PAH, GRHPR | CYP2A6 879/4885CYP1A2 216/4885ACHE 4392/4885 |
| US-20190119277-A1 | VINBLASTINE 20' AMIDES: SYNTHETIC ANALOGS THAT MAINTAIN OR IMPROVE POTENCY AND SIMULTANEOUSLY OVERCOME Pgp-DERIVED EFFLUX AND RESISTANCE | ABCG2, ABCC1, GLS | CYP2A6 614/4885CYP1A2 847/4885ACHE 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.