Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31648974 | 0.86 | MEN1 (0.42) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL6552405 | 0.81 | MEN1 (0.48) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL2763437 | 0.75 | LMNA (0.77) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL14836225 | 0.75 | LMNA (0.55) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL2611715 | 0.74 | MEN1 (0.45) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL14120878 | 0.74 | LMNA (0.44) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL2742120 | 0.74 | ALDH1A1 (0.53) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL995638 | 0.74 | ALDH1A1 (0.53) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL23601663 | 0.73 | MEN1 (0.40) | MEN1KMT2ARAB9ALMNAALDH1A1 | |
| SCHEMBL16385101 | 0.73 | LMNA (0.62) | MEN1KMT2ARAB9ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025132334-A1 | RESISTS USING PFAS FREE PAGS | MERCK PATENT GMBH (DE) | 2025-06-26 | — | — | WO | disclosed |