Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2398343 | 0.98 | TAAR1 (0.47) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL10939839 | 0.84 | TSHR (0.43) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL17275800 | 0.82 | TAAR1 (0.38) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL11729319 | 0.81 | ALDH1A1 (0.50) | TP53MAPTTSHRALDH1A1LMNA | |
| SCHEMBL10650653 | 0.80 | TSHR (0.41) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL8959902 | 0.80 | TAAR1 (0.49) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL8692711 | 0.80 | TSHR (0.41) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL2215314 | 0.80 | TSHR (0.41) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL415762 | 0.80 | TSHR (0.45) | TAAR1TP53MAPTTSHRALDH1A1 | |
| SCHEMBL479210 | 0.80 | TSHR (0.41) | TAAR1TP53MAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3177589-B1 | METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES | INTERQUIM SA (ES) | 2018-06-20 | — | — | EP | claimed |
| US-9815771-B2 | Method for the synthesis of mirabegron and its derivatives | INTERQUIM, S.A. (ES) | 2017-11-14 | — | — | US | claimed |
| US-20170226045-A1 | METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES | INTERQUIM, S.A. (ES) | 2017-08-10 | — | — | US | claimed |
| EP-3177589-A1 | METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES | Interquim, S.A. (ES) | 2017-06-14 | — | — | EP | claimed |
| EP-2817289-B1 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | CELGENE CORP (US) | 2016-12-21 | — | — | EP | claimed |
| WO-2016020440-A1 | METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES | INTERQUIM, S.A. (ES) | 2016-02-11 | — | — | WO | claimed |
| EP-2817289-A2 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | Celgene Corporation (US) | 2014-12-31 | — | — | EP | claimed |
| WO-2013126495-A2 | ASYMMETRIC SYNTHETIC PROCESSES FOR THE PREPARATION OF AMINOSULFONE COMPOUNDS | CELGENE CORPORATION (US) | 2013-08-29 | — | — | WO | claimed |
| US-8093436-B2 | Process for synthesis of (3R,3′R)-zeaxanthin and (3R,3′S;meso)-zeaxanthin from (3R,3′R,6′R)-lutein via (3R)-3′,4′-anhydrolutein | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2012-01-10 | — | — | US | claimed |
| US-20100010212-A1 | Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe | KANSAL VINOD KUMAR | 2010-01-14 | — | — | US | claimed |
| US-20090238933-A1 | Process for Synthesis of (3R,3'R)-Zeaxanthin and (3R,3'S;meso)-Zeaxanthin from (3R,3'R,6'R)-Lutein via (3R)-3',4'-Anhydrolutein | UNIVERSITY OF MARYLAND, COLLEGE PARK | 2009-09-24 | — | — | US | claimed |
| EP-1922304-A2 | PROCESSES FOR THE PREPARATION OF (3R,4S)-4-((4-BENZYLOXY)PHENYL)-1-(4-FLUOROPHENYL)-3-((S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-2-AZETIDINONE, AN INTERMEDIATE FOR THE SYNTHESIS OF EZETIMIBE | Teva Pharmaceutical Industries Ltd (IL) | 2008-05-21 | — | — | EP | claimed |
| WO-2007030721-A9 | PROCESSES FOR THE PREPARATION OF (3R,4S)-4-((4-BENZYLOXY)PHENYL)-1-(4-FLUOROPHENYL)-3-((S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-2-AZETIDINONE, AN INTERMEDIATE FOR THE SYNTHESIS OF EZETIMIBE | TEVA PHARMA (IL) | 2008-04-24 | — | — | WO | claimed |
| CN-100351284-C | Actinic radiation curable compositions and uses thereof | HUNTSMAN ADV MAT SWITZERLAND (CH) | 2007-11-28 | — | — | CN | claimed |
| US-20070259845-A1 | Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe | TEVA PHARMACEUTICALS USA, INC. | 2007-11-08 | — | — | US | claimed |
| WO-2007030721-A2 | PROCESSES FOR THE PREPARATION OF (3R,4S)-4-((4-BENZYLOXY)PHENYL)-1-(4-FLUOROPHENYL)-3-((S)-3-(4-FLUOROPHENYL)-3-HYDROXYPROPYL)-2-AZETIDINONE, AN INTERMEDIATE FOR THE SYNTHESIS OF EZETIMIBE | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-15 | — | — | WO | claimed |
| US-20060069263-A1 | Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole | CHEMAGIS LTD. (IL) | 2006-03-30 | — | — | US | claimed |
| CN-1659204-A | Actinic radiation curable compositions and uses thereof | HUNTSMAN ADV MAT SWITZERLAND (CH) | 2005-08-24 | — | — | CN | claimed |
| EP-3177589-B1 | METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES | INTERQUIM SA (ES) | 2018-06-20 | — | — | EP | disclosed |
| US-6204405-B1 | REACTING TRI-O-PHENYLENE BIS BORATE WITH DIBORANE | SIGMA-ALDRICH CO. | 2001-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060069263-A1 | Process for the reduction of (S)-2-amino-6-propionamido-4,5,6,7-tetrahydrobenzo-thiazole | TST, ABAT, TH | TAAR1 1091/4885TP53 4221/4885MAPT 890/4885 |
| US-20100010212-A1 | Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe | HMGCR, PCSK9, CYP4B1 | TAAR1 4766/4885TP53 4823/4885MAPT 4470/4885 |
| US-20070259845-A1 | Processes for the preparation of (3R,4S)-4-((4-benzyloxy)phenyl)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-2-azetidinone, an intermediate for the synthesis of ezetimibe | HMGCR, CYP4B1, PCSK9 | TAAR1 4763/4885TP53 4819/4885MAPT 4439/4885 |
| US-20090238933-A1 | Process for Synthesis of (3R,3'R)-Zeaxanthin and (3R,3'S;meso)-Zeaxanthin from (3R,3'R,6'R)-Lutein via (3R)-3',4'-Anhydrolutein | AQP3, B3GAT3, MC3R | TAAR1 2911/4885TP53 4443/4885MAPT 3628/4885 |
| US-20170226045-A1 | METHOD FOR THE SYNTHESIS OF MIRABEGRON AND ITS DERIVATIVES | ADRB3, GLP1R, ADRB1 | TAAR1 325/4885TP53 4843/4885MAPT 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.