Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PLG | P00747 | 2/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731754 | 0.83 | ALOX15 (0.49) | KDM5AKDM4CKDM5BMEN1KMT2A | |
| SCHEMBL31731771 | 0.79 | PLK1 (0.49) | KDM5AKDM4CKDM5BMEN1KMT2A | |
| SCHEMBL31731727 | 0.78 | KDM5A (0.45) | KDM5AKDM4CKDM5BMEN1KMT2A | |
| SCHEMBL9907404 | 0.76 | ALOX15 (0.52) | KDM5AKDM4CKDM5BMEN1KMT2A | |
| SCHEMBL31731738 | 0.76 | GPBAR1 (0.46) | KDM5AKDM4CKDM5BCSNK2A2CSNK2B | |
| SCHEMBL30228312 | 0.75 | KCNA3 (0.46) | KMT2AALDH1A1CYP1A2 | |
| SCHEMBL31731473 | 0.74 | TGFBR1 (0.50) | KDM5AKDM4CKDM5BMEN1KMT2A | |
| SCHEMBL31731728 | 0.73 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1CYP1A2HTT | |
| SCHEMBL31731723 | 0.73 | PLA2G7 (0.53) | MEN1KMT2APLA2G7ALDH1A1MAPK1 | |
| SCHEMBL9907406 | 0.72 | KDM4C (0.52) | KDM5AKDM4CKDM5BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250353816-A1 | QUINOLINES AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250353816-A1 | QUINOLINES AS MODULATORS OF POLRMT | POLRMT, POLM, TFAM | KDM5A 2220/4885KDM4C 2176/4885KDM5B 1722/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.