Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 5/20 | 0.38 |
| ▸ | CASP7 | P55210 | 2/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | REN | P00797 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3182350 | 0.93 | KDM4E (0.39) | KDM4EMEN1KMT2AMAPTRECQL | |
| SCHEMBL3175794 | 0.89 | CASP3 (0.46) | KDM4EMEN1KMT2AMAPTRECQL | |
| SCHEMBL3181740 | 0.87 | CASP3 (0.41) | KDM4EMEN1KMT2AMAPTRECQL | |
| SCHEMBL3177183 | 0.82 | CRHBP (0.37) | CASP3CASP7CASP8BRD4CASP9 | |
| SCHEMBL3183117 | 0.82 | ALDH1A1 (0.34) | KDM4EMEN1KMT2ACASP3CASP7 | |
| SCHEMBL3166284 | 0.81 | CASP3 (0.47) | KDM4EMEN1KMT2AMAPTRECQL | |
| SCHEMBL3964779 | 0.79 | CASP3 (0.37) | CASP3CASP7CASP8RENCTSK | |
| SCHEMBL4258250 | 0.79 | CASP3 (0.38) | MEN1KMT2ACASP3CASP7CASP8 | |
| SCHEMBL8205974 | 0.75 | BRD4 (0.47) | KDM4EMEN1KMT2AMAPTRECQL | |
| SCHEMBL4258853 | 0.75 | NPBWR1 (0.38) | KDM4EMEN1KMT2ACASP3CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016376-A1 | CASPASE INHIBITORS BASED ON PYRIDONE SCAFFOLD | LG LIFE SCIENCES LTD. (KR) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016376-A1 | CASPASE INHIBITORS BASED ON PYRIDONE SCAFFOLD | CASP1, CASP5, CASP2 | KDM4E 1345/4885MEN1 3320/4885KMT2A 4046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.