Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 7/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.42 |
| ▸ | CCR3 | P51677 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3196716 | 0.92 | NPC1 (0.53) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3196895 | 0.92 | RORC (0.45) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4237706 | 0.92 | RORC (0.48) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3196731 | 0.91 | RORC (0.50) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3209526 | 0.90 | RORC (0.43) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5070131 | 0.90 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| Omecamtiv Mecarbil SCHEMBL400544 | 0.90 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| Omecamtiv Mecarbil SCHEMBL29400097 | 0.90 | RORC (0.47) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3191075 | 0.90 | RORC (0.43) | RORCDHODHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3214918 | 0.89 | RORC (0.49) | RORCDHODHNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070161617-A1 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. | 2007-07-12 | — | — | US | claimed |
| US-20240217933-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. | 2024-07-04 | — | — | US | disclosed |
| US-20230149394-A1 | METHODS OF TREATING HEART FAILURE WITH CARDIAC SARCOMERE ACTIVATORS | CYTOKINETICS, INC. | 2023-05-18 | — | — | US | disclosed |
| US-9988354-B2 | Salt of omecamtiv mecarbil and process for preparing salt | AMGEN INC. (US) | 2018-06-05 | — | — | US | disclosed |
| US-9951015-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-9895308-B2 | Heterocyclic compounds and their uses | AMGEN INC. (US) | 2018-02-20 | — | — | US | disclosed |
| US-20160015628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | CYTOKINETICS, INC. | 2016-01-21 | — | — | US | disclosed |
| US-20160016906-A1 | SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT | AMGEN INC. (US) | 2016-01-21 | — | — | US | disclosed |
| US-8871768-B2 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20140309235-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | CYTOKINETICS, INC. (US) | 2014-10-16 | — | — | US | disclosed |
| US-20130324549-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2013-12-05 | — | — | US | disclosed |
| US-8445495-B2 | Certain Chemical entities, compositions and methods | CYTOKINETICS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100029680-A1 | Certain Chemical Entities, Compositions and Methods | CYTOKINETICS, INC. | 2010-02-04 | — | — | US | disclosed |
| EP-1959960-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| US-20070161617-A1 | Certain chemical entities, compositions and methods | CYTOKINETICS, INC. | 2007-07-12 | — | — | US | disclosed |
| WO-2007070683-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-06-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160015628-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | SI, MLN, MLNR | RORC 1066/4885DHODH 630/4885NPC1 4364/4885 |
| US-20070161617-A1 | Certain chemical entities, compositions and methods | TNNI3, TNNT2, MYLK2 | RORC 2972/4885DHODH 3762/4885NPC1 4691/4885 |
| US-20140309235-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | SI, MLN, MLNR | RORC 1066/4885DHODH 630/4885NPC1 4364/4885 |
| US-20230149394-A1 | METHODS OF TREATING HEART FAILURE WITH CARDIAC SARCOMERE ACTIVATORS | TNNC1, TNNT2, TNNI3 | RORC 4596/4885DHODH 4430/4885NPC1 3266/4885 |
| US-20130324549-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | TNNI3, TNNT2, MYLK2 | RORC 2972/4885DHODH 3762/4885NPC1 4691/4885 |
| US-20100029680-A1 | Certain Chemical Entities, Compositions and Methods | TNNI3, TNNT2, MYLK2 | RORC 2972/4885DHODH 3762/4885NPC1 4691/4885 |
| US-20240217933-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | SI, MLN, MLNR | RORC 1066/4885DHODH 630/4885NPC1 4364/4885 |
| US-20160016906-A1 | SALT OF OMECAMTIV MECARBIL AND PROCESS FOR PREPARING SALT | SI, AREG, CA12 | RORC 1000/4885DHODH 672/4885NPC1 4459/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.