Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.53 |
| ▸ | CNR1 | P21554 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | IDE | P14735 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 6/20 | 0.45 |
| ▸ | CA1 | P00915 | 6/20 | 0.45 |
| ▸ | CA2 | P00918 | 6/20 | 0.45 |
| ▸ | CA9 | Q16790 | 6/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10088098 | 0.90 | TDP1 (0.59) | TDP1CNR1MEN1ABL1LMNA | |
| SCHEMBL318637 | 0.87 | TDP1 (0.61) | TDP1MEN1ABL1LMNAPKM | |
| Biotin SCHEMBL4360688 | 0.83 | TDP1 (0.64) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL319055 | 0.80 | TDP1 (0.67) | TDP1CNR1MEN1ABL1LMNA | |
| SCHEMBL5903549 | 0.78 | TDP1 (0.48) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL10002269 | 0.77 | TDP1 (0.67) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL13888577 | 0.77 | TDP1 (0.67) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL1727527 | 0.77 | TDP1 (0.67) | TDP1MEN1ABL1LMNAPKM | |
| SCHEMBL12724896 | 0.77 | TDP1 (0.68) | TDP1CNR1MEN1ABL1LMNA | |
| SCHEMBL19901346 | 0.77 | TDP1 (0.68) | TDP1CNR1MEN1ABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684810-B1 | Polybiotin compounds for magnetic resonance imaging and drug delivery | GEN HOSPITAL CORP (US) | 2013-09-25 | — | — | EP | disclosed |
| US-8092782-B2 | Polybiotin compounds of magnetic resonance imaging and drug delivery | THE GENERAL HOSPITAL CORPORATION (US) | 2012-01-10 | — | — | US | disclosed |
| EP-1684810-A4 | POLYBIOTIN COMPOUNDS FOR MAGNETIC RESONANCE IMAGINING AND DRUG DELIVERY | GEN HOSPITAL CORP (US) | 2009-05-27 | — | — | EP | disclosed |
| US-20090010845-A1 | Polybiotin Compounds of Magnetic Resonance Imaging and Drug Delivery | THE GENERAL HOSPITAL CORPORATION (US) | 2009-01-08 | — | — | US | disclosed |
| US-7438893-B2 | Polybiotin compounds for magnetic resonance imaging and drug delivery | MASSACHUSETTS GENERAL HOSPITAL (US) | 2008-10-21 | — | — | US | disclosed |
| EP-1684810-A1 | POLYBIOTIN COMPOUNDS FOR MAGNETIC RESONANCE IMAGINING AND DRUG DELIVERY | THE GENERAL HOSPITAL CORPORATION (US) | 2006-08-02 | — | — | EP | disclosed |
| US-20050136008-A1 | Polybiotin compounds for magnetic resonance imaging and drug delivery | MASSACHUSETTS GENERAL HOSPITAL (US) | 2005-06-23 | — | — | US | disclosed |
| WO-2005032598-A1 | POLYBIOTIN COMPOUNDS FOR MAGNETIC RESONANCE IMAGINING AND DRUG DELIVERY | THE GENERAL HOSPITAL CORPORATION (US) | 2005-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050136008-A1 | Polybiotin compounds for magnetic resonance imaging and drug delivery | BTD, BCAT1, BRD4 | TDP1 3602/4885CNR1 2063/4885MEN1 333/4885 |
| US-20090010845-A1 | Polybiotin Compounds of Magnetic Resonance Imaging and Drug Delivery | BTD, BCAT1, BRD4 | TDP1 3576/4885CNR1 2024/4885MEN1 336/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.