Sugi Predict

Sugi Predict / Compounds / SCHEMBL319381

SCHEMBL319381

SCHEMBL319381

COC(=O)c1ncc(F)cc1N

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPSR1 Q6W5P4 1/20 0.41
▸ KDM4E B2RXH2 7/20 0.40
▸ ALDH1A1 P00352 6/20 0.40
▸ GAA P10253 3/20 0.40
▸ GLA P06280 2/20 0.40
▸ IKBKB O14920 1/20 0.40
▸ CFTR P13569 4/20 0.39
▸ MAPT P10636 3/20 0.38
▸ HPGD P15428 3/20 0.38
▸ OPRK1 P41145 1/20 0.38
▸ HSD17B10 Q99714 4/20 0.38
▸ TSHR P16473 2/20 0.38
▸ CASP1 P29466 1/20 0.38
▸ CASP7 P55210 1/20 0.38
▸ ATM Q13315 1/20 0.38
▸ APP P05067 1/20 0.37
▸ BACE1 P56817 1/20 0.37
▸ BACE2 Q9Y5Z0 1/20 0.37
▸ ABL1 P00519 1/20 0.37
▸ SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL644695 0.82 NPSR1 (0.43) NPSR1KDM4EALDH1A1GAAMAPT
SCHEMBL29738141 0.82 NPSR1 (0.43) NPSR1KDM4EALDH1A1GAAMAPT
SCHEMBL27667113 0.82 IKBKB (0.50) KDM4EALDH1A1IKBKBMAPTHPGD
SCHEMBL14260604 0.81 OPRK1 (0.47) NPSR1KDM4EALDH1A1GAAGLA
SCHEMBL18124754 0.81 ATM (0.47) NPSR1KDM4EALDH1A1GAAGLA
SCHEMBL2592299 0.81 AGBL2 (0.47) NPSR1KDM4EALDH1A1OPRK1HSD17B10
SCHEMBL11978270 0.80 AGBL2 (0.39) KDM4ECFTRMAPTAPPBACE1
SCHEMBL30259690 0.80 AGBL2 (0.39) KDM4ECFTRMAPTAPPBACE1
SCHEMBL14067964 0.79 APP (0.33) CFTRAPPBACE1BACE2
SCHEMBL16632434 0.79 NPSR1 (0.41) NPSR1KDM4EALDH1A1OPRK1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 197 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4724070-A2 WRN INHIBITORS Nimbus Wadjet, Inc. (US) 2026-04-15 — — EP disclosed
US-20260098018-A1 BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF CYTOKINETICS INC (US) 2026-04-09 — — US disclosed
EP-4695256-A2 ERBB2 INHIBITORS Cogent Biosciences, Inc. (US) 2026-02-18 — — EP disclosed
US-12528806-B2 WRN inhibitors NIMBUS WADJET, INC. (US) 2026-01-20 — — US disclosed
WO-2025264954-A1 PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF COMPLEMENT MEDIATED DISORDERS ALEXION PHARMACEUTICALS, INC. (US) 2025-12-26 — — WO disclosed
US-12441691-B2 Bicyclic 1,4-diazepanones and therapeutic uses thereof CYTOKINETICS, INC. (US) 2025-10-14 — — US disclosed
US-12421233-B2 WRN inhibitors NIMBUS WADJET, INC. (US) 2025-09-23 — — US disclosed
US-12377100-B2 Toll like receptor modulator compounds GILEAD SCIENCES, INC. (US) 2025-08-05 — — US disclosed
US-12344609-B2 WRN inhibitors NIMBUS WADJET, INC. (US) 2025-07-01 — — US disclosed
WO-2025137599-A1 WRN INHIBITORS NIMBUS WADJET, INC. (US) 2025-06-26 — — WO disclosed
US-20130109682-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2013-05-02 — — US disclosed
US-20130109682-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2013-05-02 — — US disclosed
WO-2012120415-A1 TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS NOVARTIS AG (CH) 2012-09-13 — — WO disclosed
US-20120225061-A1 TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2012-09-06 — — US disclosed
US-20120225061-A1 TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS NOVARTIS VACCINES AND DIAGNOSTICS, INC. 2012-09-06 — — US disclosed
US-20120208815-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2012-08-16 — — US disclosed
US-20120208815-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS AG (CH) 2012-08-16 — — US disclosed
WO-2012004217-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS NOVARTIS AG (CH) 2012-01-12 — — WO disclosed
EP-2132177-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE Novartis Ag (CH) 2009-12-16 — — EP disclosed
WO-2008106692-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE NOVARTIS VACCINES AND DIAGNOSTICS, INC. (US) 2008-09-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130109682-A1 CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS PIM1, GSK3A, GSK3B NPSR1 4638/4885KDM4E 636/4885ALDH1A1 2437/4885
US-12421233-B2 WRN inhibitors WRN, BLM, RECQL NPSR1 4764/4885KDM4E 3350/4885ALDH1A1 3002/4885
US-12344609-B2 WRN inhibitors WRN, BLM, RECQL NPSR1 4756/4885KDM4E 2662/4885ALDH1A1 3196/4885
US-12441691-B2 Bicyclic 1,4-diazepanones and therapeutic uses thereof MYLK2, MUSK, MYLK NPSR1 3271/4885KDM4E 1838/4885ALDH1A1 3140/4885
US-12377100-B2 Toll like receptor modulator compounds TLR8, TLR3, TLR6 NPSR1 939/4885KDM4E 1694/4885ALDH1A1 3811/4885
US-20120208815-A1 PIM KINASE INHIBITORS AND METHODS OF THEIR USE PIM1, PIM2, PIM3 NPSR1 4157/4885KDM4E 946/4885ALDH1A1 2176/4885
US-20260098018-A1 BICYCLIC 1,4-DIAZEPANONES AND THERAPEUTIC USES THEREOF MYLK2, TNNT2, RYR1 NPSR1 3131/4885KDM4E 1026/4885ALDH1A1 3721/4885
US-12528806-B2 WRN inhibitors WRN, RECQL, BLM NPSR1 4456/4885KDM4E 1099/4885ALDH1A1 1817/4885
US-20120225061-A1 TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS PIM1, PIM2, PIM3 NPSR1 4053/4885KDM4E 1008/4885ALDH1A1 2104/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.