Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3198438 | 0.97 | MAPT (0.37) | MAPTKDM4ELMNAHTTRAB9A | |
| SCHEMBL3198441 | 0.97 | MAPT (0.37) | MAPTKDM4ELMNAHTTRAB9A | |
| SCHEMBL13418972 | 0.97 | MAPT (0.37) | MAPTKDM4ELMNAHTTRAB9A | |
| Hydrochloric Acid SCHEMBL3208211 | 0.82 | TAAR1 (0.31) | KDM4E | |
| SCHEMBL12021102 | 0.81 | RAB9A (0.36) | MAPTKDM4ELMNAHTTRAB9A | |
| SCHEMBL3195185 | 0.81 | RAB9A (0.36) | MAPTKDM4ELMNAHTTRAB9A | |
| SCHEMBL12020994 | 0.79 | MAPT (0.34) | MAPTKDM4EKMT2A | |
| SCHEMBL3209293 | 0.78 | KDM4E (0.32) | MAPTKDM4ELMNAHTTRAB9A | |
| SCHEMBL14804878 | 0.78 | KDM4E (0.32) | MAPTKDM4ELMNAHTTRAB9A | |
| SCHEMBL3193450 | 0.75 | NPY5R (0.39) | MAPTKDM4ELMNAHTTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683149-B2 | Catalysts for olefin polymerization or oligomerization | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-03-23 | — | — | US | disclosed |
| US-20080287621-A1 | Catalysts for olefin polymerization or oligomerization | DUPONT POLYMERS, INC. | 2008-11-20 | — | — | US | disclosed |
| US-7442819-B2 | Catalysts for olefin polymerization or oligomerization | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-10-28 | — | — | US | disclosed |
| US-20060009597-A1 | Catalysts for olefin polymerization or oligomerization | DUPONT POLYMERS, INC. | 2006-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060009597-A1 | Catalysts for olefin polymerization or oligomerization | PPOX, HMOX1, NOD2 | MAPT 525/4885KDM4E 3147/4885LMNA 3782/4885 |
| US-20080287621-A1 | Catalysts for olefin polymerization or oligomerization | PPOX, HMOX1, NOD2 | MAPT 525/4885KDM4E 3147/4885LMNA 3782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.