Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 4/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.78 |
| ▸ | NR3C1 | P04150 | 13/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.76 |
| ▸ | AR | P10275 | 2/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.76 |
| ▸ | TNF | P01375 | 1/20 | 0.76 |
| ▸ | IL6 | P05231 | 1/20 | 0.76 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.76 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.76 |
| ▸ | GLUL | P15104 | 1/20 | 0.76 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.76 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | F2 | P00734 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8020744 | 1.00 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL8020748 | 1.00 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL5524342 | 0.93 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL13596192 | 0.89 | PGR (0.83) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL13368125 | 0.89 | PGR (0.83) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL9069792 | 0.89 | HIF1A (0.71) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL15662128 | 0.88 | PGR (0.78) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| SCHEMBL23633793 | 0.88 | PGR (0.81) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Acetate SCHEMBL10118889 | 0.88 | HIF1A (1.00) | PGRHIF1ANR3C1HSD17B10CYP3A4 | |
| Prednisolone Acetate SCHEMBL13044467 | 0.88 | HIF1A (1.00) | PGRHIF1ANR3C1HSD17B10CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100056488-A1 | CORTICOSTEROID CONJUGATES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2010-03-04 | — | — | US | disclosed |
| EP-1850855-A2 | COMPOUNDS AND USES THEREOF | Combinatorx, Incorporated (US) | 2007-11-07 | — | — | EP | disclosed |
| US-20060281722-A1 | Compounds and uses thereof | COMBINATORX, INC. | 2006-12-14 | — | — | US | disclosed |
| EP-1562627-A4 | CORTICOSTEROID CONJUGATES AND USES THEREOF | MCLEAN HOSPITAL CORP (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2006088786-A2 | COMPOUNDS AND USES THEREOF | COMBINATORX, INCORPORATED (US) | 2006-08-24 | — | — | WO | disclosed |
| EP-1562627-A2 | CORTICOSTEROID CONJUGATES AND USES THEREOF | The McLean Hospital Corporation (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040157810-A1 | Corticosteroid conjugates and uses thereof | MCLEAN HOSPITAL CORPORATION, THE | 2004-08-12 | — | — | US | disclosed |
| WO-2004017904-A2 | CORTICOSTEROID CONJUGATES AND USES THEREOF | THE MCLEAN HOSPITAL CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |
| US-4404141-A | Δ9(11) - And Δ16 -21-chloro-20-keto steroids of the pregnane and D-homopregnane series, their preparation and use as intermediates for the synthesis of highly effective corticoids | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-09-13 | — | — | US | disclosed |
| EP-0014005-B1 | NOVEL ALKYLATED PREGNANES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AKZO N.V. (NL) | 1983-08-03 | — | — | EP | disclosed |
| EP-0014005-A1 | Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same | AKZO N.V. (NL) | 1980-08-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157810-A1 | Corticosteroid conjugates and uses thereof | NR3C1, NR3C2, C3AR1 | PGR 515/4885HIF1A 4459/4885NR3C1 1/4885 |
| US-20060281722-A1 | Compounds and uses thereof | BDNF, TPH1, TPH2 | PGR 1134/4885HIF1A 1866/4885NR3C1 83/4885 |
| US-20100056488-A1 | CORTICOSTEROID CONJUGATES AND USES THEREOF | NR3C1, NR3C2, C3AR1 | PGR 515/4885HIF1A 4459/4885NR3C1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.