Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Octocrylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Octocrylene SCHEMBL3158652 | 0.93 | ALDH1A1 (0.81) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL16483 | 0.91 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL1769135 | 0.91 | ALDH1A1 (1.00) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL28123035 | 0.90 | ALDH1A1 (0.98) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL19583477 | 0.89 | ALDH1A1 (0.95) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL9015793 | 0.89 | ALDH1A1 (0.79) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| SCHEMBL16806267 | 0.88 | ALDH1A1 (0.89) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL818975 | 0.88 | ALDH1A1 (0.93) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| Octocrylene SCHEMBL8180706 | 0.88 | ALDH1A1 (0.93) | ALDH1A1LMNAMAPK1CYP3A4CA2 | |
| SCHEMBL13492185 | 0.88 | ALDH1A1 (0.93) | ALDH1A1LMNAMAPK1CYP3A4CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100047197-A1 | COSMETIC FORMULATION CONTANING GLUCOSYL GLYCERIDES AND UREA | BEIERSDORF AG (DE) | 2010-02-25 | — | — | US | claimed |
| EP-2854770-B1 | METHOD FOR PREPARING A DERMATOLOGICAL COMPOSITION INCLUDING OLEOSOMES | GALDERMA RES & DEV (FR) | 2019-04-17 | — | — | EP | disclosed |
| EP-0418443-A1 | Waterproof sunscreen | NEUTROGENA CORPORATION (US) | 1991-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100047197-A1 | COSMETIC FORMULATION CONTANING GLUCOSYL GLYCERIDES AND UREA | UGCG, UGGT1, GLA | ALDH1A1 1038/4885LMNA 1629/4885MAPK1 4311/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.