Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.50 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.39 |
| ▸ | KHK | P50053 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12225935 | 0.87 | PTGIR (0.43) | MEN1KMT2A | |
| SCHEMBL2392197 | 0.83 | EP300 (0.38) | GBA1SLC6A4SLC6A2KHK | |
| SCHEMBL5406716 | 0.83 | CHRM5 (0.39) | GBA1 | |
| SCHEMBL15998771 | 0.81 | TRPV1 (0.46) | MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL5412255 | 0.81 | CHRM5 (0.38) | GBA1 | |
| SCHEMBL31381408 | 0.79 | EP300 (0.41) | GBA1USP30SLC6A4SLC6A2 | |
| SCHEMBL5651526 | 0.76 | GBA1 (0.56) | GBA1SIGMAR1USP30MAOBMAOA | |
| SCHEMBL3042636 | 0.76 | ACHE (0.46) | GBA1USP30MAOAMEN1KMT2A | |
| SCHEMBL4071618 | 0.75 | HTT (0.46) | GBA1USP30MAOBHRH1MEN1 | |
| Hydrochloric Acid SCHEMBL8332334 | 0.74 | ACHE (0.45) | GBA1USP30MAOAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115776887-A | MDM2 degrading agents and uses thereof | 凯麦拉医疗公司 | 2023-03-10 | — | — | CN | disclosed |
| US-8519139-B2 | Indazolamides with analgesic activity | Aziende Chimeche Riunite Angelini Francesco A.C.R.A.F. S.p.A. (IT) | 2013-08-27 | — | — | US | disclosed |
| US-8507528-B2 | 2-alkyl-indazole compounds for the treatment of certain cns-related disorders | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2013-08-13 | — | — | US | disclosed |
| EP-2099780-B1 | 2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | ACRAF (IT) | 2013-01-09 | — | — | EP | disclosed |
| US-20100056573-A1 | 2-ALKYL-INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2010-03-04 | — | — | US | disclosed |
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A. (IT) | 2010-02-25 | — | — | US | disclosed |
| US-7638534-B2 | Use of indazole derivatives for the treatment of neuropathic pain | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-29 | — | — | US | disclosed |
| US-7632849-B2 | N3-((1-(2-Oxo-2-(phenylamino)ethyl)-4-piperidyl)methyl)- 1-(1-methylethyl)-1H-indazole-3-carboxamide; antiarthritic agents; rheumatic diseases; osteoarthritis; fibromyaleia;anticarcinogenic agents, pain; neuropathic pain; immunoincompetance; trauma; antiischemic agents; multiple sclerosis | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2009-12-15 | — | — | US | disclosed |
| EP-2099780-A1 | 2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2009-09-16 | — | — | EP | disclosed |
| WO-2008061688-A1 | 2 -ALKYL- INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2008-05-29 | — | — | WO | disclosed |
| EP-1646387-B1 | USE OF INDAZOLE DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN | ACRAF (IT) | 2006-11-15 | — | — | EP | disclosed |
| US-20060183775-A1 | Use of indazole derivatives for the treatment of neuropathic pain | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A. (IT) | 2006-08-17 | — | — | US | disclosed |
| US-20060052417-A1 | Indazolamides with analgesic activity | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2006-03-09 | — | — | US | disclosed |
| EP-1594859-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004074275-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2004-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056573-A1 | 2-ALKYL-INDAZOLE COMPOUNDS FOR THE TREATMENT OF CERTAIN CNS-RELATED DISORDERS | CYP11B2, CYP1A2, INA | GBA1 195/4885SLC18A3 385/4885SIGMAR1 1349/4885 |
| US-20060183775-A1 | Use of indazole derivatives for the treatment of neuropathic pain | SCN3A, OPRD1, SCN1A | GBA1 363/4885SLC18A3 632/4885SIGMAR1 32/4885 |
| US-20100048907-A1 | INDAZOLAMIDES WITH ANALGESIC ACTIVITY | TRPV1, CA2, TRPV2 | GBA1 1348/4885SLC18A3 582/4885SIGMAR1 178/4885 |
| US-20060052417-A1 | Indazolamides with analgesic activity | P2RX7, P2RX3, P2RX1 | GBA1 1354/4885SLC18A3 2681/4885SIGMAR1 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.