Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2252055 | 0.84 | NOS3 (0.45) | NOS3NOS2CNR1MCHR1ASIC3 | |
| SCHEMBL10490484 | 0.74 | HRH3 (0.42) | NOS3NOS2CNR1MCHR1NOS1 | |
| SCHEMBL20689246 | 0.73 | MCHR1 (0.36) | NOS3NOS2MCHR1DHFRNOS1 | |
| SCHEMBL1097604 | 0.73 | NOS3 (0.50) | NOS3NOS2MCHR1ASIC3NOS1 | |
| SCHEMBL29907766 | 0.73 | NOS3 (0.50) | NOS3NOS2MCHR1ASIC3NOS1 | |
| SCHEMBL23104383 | 0.72 | HRH3 (0.59) | NOS3NOS2NOS1 | |
| SCHEMBL29736634 | 0.72 | HRH3 (0.59) | NOS3NOS2NOS1 | |
| SCHEMBL19121972 | 0.72 | CRHR1 (0.39) | NOS3NOS2CNR1CRHR1 | |
| SCHEMBL10056763 | 0.72 | HCAR3 (0.39) | HCAR3CRHR1DHFR | |
| SCHEMBL16002391 | 0.72 | LMNA (0.41) | CNR1HCAR3CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084569-B2 | Process for the synthesis of diaminopyridines from glutarimidines | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2011-12-27 | — | — | US | disclosed |
| US-20100056749-A1 | PROCESS FOR THE SYNTHESIS OF DIAMINOPYRIDINES FROM GLUTARIMIDINES | E. I. DU PONT DE NEMOURS AND COMPANY | 2010-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056749-A1 | PROCESS FOR THE SYNTHESIS OF DIAMINOPYRIDINES FROM GLUTARIMIDINES | DPYD, GCDH, OGDH | NOS3 2512/4885NOS2 1421/4885CNR1 4308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.