Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | GRK2 | P25098 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1722529 | 0.87 | PTGS2 (0.46) | AKR1B1PTGS1PTGS2NSD2POLB | |
| SCHEMBL13989142 | 0.84 | MAP4K4 (0.37) | POLBKDM4EALDH1A1HTTMAPT | |
| SCHEMBL3258935 | 0.84 | ALOX15 (0.34) | PTGS1PTGS2KDM4EALDH1A1GAA | |
| SCHEMBL25515658 | 0.76 | KDM4E (0.38) | POLBKDM4EALDH1A1GAAHTT | |
| SCHEMBL12480176 | 0.74 | ALDH1A1 (0.49) | AKR1B1NSD2POLBGRK2CASP6 | |
| SCHEMBL27283340 | 0.73 | CALM1 (0.42) | KDM4EALDH1A1TDP1MAPTCHEK1 | |
| Acetic Acid SCHEMBL28086771 | 0.73 | TBXAS1 (0.43) | PTGS1PTGS2ALDH1A1MAPT | |
| SCHEMBL28840463 | 0.72 | KDM4E (0.37) | POLBKDM4EALDH1A1GAAHTT | |
| SCHEMBL7169853 | 0.72 | ALDH1A1 (0.37) | POLBKDM4EALDH1A1GAAHTT | |
| SCHEMBL6949233 | 0.72 | KDM4E (0.37) | PTGS2POLBKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102365281-B | Indolizine derivative and medical application thereof | KISSEI PHARMACEUTICAL | 2014-11-12 | — | — | CN | disclosed |
| CN-104136431-A | PYRIDINONE AND PYRIMIDINONE DERIVATIVES AS FACTOR XIA INHIBITORS | ONO PHARMACEUTICAL CO | 2014-11-05 | — | — | CN | disclosed |
| WO-2010009403-A2 | METHODS FOR TREATING ARTHRITIS AND OTHER INFLAMMATORY OR AUTOIMMUNE DISEASES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| US-6645976-B1 | Nonpancreatic secretory phospholipase (sPLA2) supressors such as 2-(3-Benzyl-8-hydroxy-2-ethylindolizin-1-yl)acetamide, administered to control release of fatty acid and prevent the arachidonic acid cascade; septic shock | ELI LILLY AND COMPANY | 2003-11-11 | — | — | US | disclosed |
| EP-0772596-B1 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-10-01 | — | — | EP | disclosed |
| EP-0772596-A4 | INDOLIZINE sPLA2 INHIBITORS | LILLY CO ELI (US) | 1999-01-13 | — | — | EP | disclosed |
| CN-1158121-A | Indolizine sPLA2Inhibitors | LILLY CO ELI (US) | 1997-08-27 | — | — | CN | disclosed |
| EP-0772596-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| WO-1996003383-A1 | INDOLIZINE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |