Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.43 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3119443 | 0.87 | SIRT1 (0.54) | ADORA1ADORA2BADORA3ADORA2ASIRT1 | |
| SCHEMBL13247927 | 0.86 | ADORA2B (0.53) | ADORA1ADORA2BADORA3ADORA2ASIRT1 | |
| SCHEMBL13247926 | 0.86 | ADORA2B (0.53) | ADORA1ADORA2BADORA3ADORA2ASIRT1 | |
| SCHEMBL7031457 | 0.86 | SIRT1 (0.55) | ADORA1ADORA2BADORA3ADORA2ASIRT1 | |
| SCHEMBL3120574 | 0.84 | RXFP1 (0.47) | ADORA1ADORA2BADORA3ADORA2AHPGD | |
| SCHEMBL837397 | 0.83 | HTR1A (0.52) | ADORA1HSD17B10ADORA2BADORA2AMAPK1 | |
| SCHEMBL13247833 | 0.83 | TP53 (0.43) | TLR7ADORA1HSD17B10TP53ALOX15 | |
| SCHEMBL3121598 | 0.81 | ADORA1 (0.53) | ADORA1ADORA2BADORA3ADORA2AKMT2A | |
| SCHEMBL3179805 | 0.81 | SIRT1 (0.54) | ADORA1HSD17B10ADORA2BADORA3ADORA2A | |
| SCHEMBL838168 | 0.81 | ADORA3 (0.49) | ADORA1HSD17B10ADORA2BADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | SMITHKLINE BEECHAM CORPORATION | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179128-A1 | XANTHINE DERIVATIVES AS SELECTIVE HM74A AGONISTS | XDH, GPR84, GPR88 | TLR7 123/4885ADORA1 32/4885HSD17B10 1026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.