Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3240957 | 0.86 | GRIN2B (0.41) | METMAPK1 | |
| SCHEMBL3241068 | 0.84 | CYP11B2 (0.41) | CYP11B2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL3245592 | 0.82 | ALDH1A1 (0.37) | METMAPK1CCKBRKDM4EALDH1A1 | |
| SCHEMBL13521571 | 0.81 | USP2 (0.42) | MAPK1KDM4EALDH1A1 | |
| SCHEMBL3246493 | 0.77 | FNTA (0.39) | CYP11B2MAPK1KDM4EALDH1A1 | |
| SCHEMBL3246489 | 0.76 | CYP11B2 (0.36) | CYP11B2KDM4EALDH1A1BMPR1BBMPR1A | |
| SCHEMBL3128762 | 0.75 | SMN1; SMN2 (0.42) | CYP11B2MAPK1KDM4EALDH1A1 | |
| SCHEMBL3130951 | 0.73 | ESR1 (0.43) | CYP11B2MAPK1KDM4EALDH1A1 | |
| SCHEMBL3118590 | 0.73 | ESR2 (0.45) | CYP11B2MAPK1KDM4EALDH1A1 | |
| SCHEMBL9532098 | 0.71 | PLA2G10 (0.40) | CCKBRKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010008777-A2 | FUSED AZABICYCLIC PYRIDINES | LIGAND PHARMACEUTICALS INC. (US) | 2010-01-21 | — | — | WO | disclosed |