Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1987774 | 0.91 | MAOB (0.46) | LMNAPOLBACHETSHRALOX12 | |
| SCHEMBL5056468 | 0.89 | CYP2A6 (0.50) | POLBACHETDP1L3MBTL1MAPK1 | |
| SCHEMBL21179476 | 0.86 | CYP2A6 (0.48) | POLBACHETDP1L3MBTL1MAPK1 | |
| SCHEMBL69726 | 0.84 | MAOB (0.57) | LMNATSHRALOX12L3MBTL1MAOB | |
| SCHEMBL4953933 | 0.82 | TP53 (0.48) | LMNAACHETDP1MAOBMAOA | |
| SCHEMBL7757955 | 0.81 | TACR1 (0.39) | MAOBMAOACYP2A6ALDH1A1HPGD | |
| SCHEMBL3274573 | 0.79 | NFE2L2 (0.57) | LMNAACHEGAASMN1; SMN2HTT | |
| SCHEMBL3844786 | 0.79 | MAOB (0.48) | LMNATDP1L3MBTL1MAPK1MAOB | |
| SCHEMBL4348469 | 0.78 | ESR1 (0.45) | LMNATDP1MAOBMAOACYP2C19 | |
| SCHEMBL8840747 | 0.78 | SIGMAR1 (0.44) | LMNAPOLBTSHRTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101544581-B | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI SEIYAKU CO | 2013-02-06 | — | — | CN | claimed |
| EP-1310487-B1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI SEIYAKU CO (JP) | 2007-01-03 | — | — | EP | claimed |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. | 2005-12-08 | — | — | US | claimed |
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-01-29 | — | — | US | claimed |
| EP-1310487-A1 | PROCESSES FOR PREPARATION OF BICYCLIC COMPOUNDS AND INTERMEDIATES THEREFOR | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2003-05-14 | — | — | EP | claimed |
| US-6479492-B1 | TREATMENT OF INFLAMMATORY DISEASES IN A MAMMALIAN PATIENT | ELAN PHARMACEUTICALS, INC. | 2002-11-12 | — | — | US | claimed |
| US-4611063-A | Silicon-bearing amides | SANDOZ CORP. (US) | 1986-09-09 | — | — | US | claimed |
| US-4512898-A | ORGANOSILANE DERIVATIVES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1985-04-23 | — | — | US | claimed |
| EP-0044158-B1 | NOVEL OPTICALLY ACTIVE IMIDAZOLIDIN-2-ONE DERIVATIVES AND THEIR PRODUCTION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1984-08-15 | — | — | EP | claimed |
| US-4420475-A | ANTICHOLESTEROL AGENTS, SILANATION | SANDOZ, INC. (US) | 1983-12-13 | — | — | US | claimed |
| US-4415560-A | ANTICHOLESTEROL AGENTS; ATHEROSCLEROSIS | SANDOZ, INC. (US) | 1983-11-15 | — | — | US | claimed |
| EP-0044158-A1 | Novel optically active imidazolidin-2-one derivatives and their production | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-01-20 | — | — | EP | claimed |
| US-4296240-A | ANTI-ATHEROSCLEROTIC AGENTS | SANDOZ, INC. (US) | 1981-10-20 | — | — | US | claimed |
| CN-101544581-B | Processes for preparation of bicyclic compounds and intermediates therefor | DAIICHI SEIYAKU CO | 2013-02-06 | — | — | CN | disclosed |
| US-8338391-B2 | Phosphine-borane compound and method for producing the same, and method for producing hydrogen-phosphine-borane compound | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2012-12-25 | — | — | US | disclosed |
| US-20100152489-A1 | NEW PHOSPHINE-BORANE COMPOUND AND METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING HYDROGEN-PHOSPHINE-BORANE COMPOUND | NIPPON CHEMICAL INDUSTRIAL CO., LTD. (JP) | 2010-06-17 | — | — | US | disclosed |
| US-4296240-A | ANTI-ATHEROSCLEROTIC AGENTS | SANDOZ, INC. (US) | 1981-10-20 | — | — | US | disclosed |
| EP-0025569-A2 | Silicon-bearing amides, their production, intermediates in their production, and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1981-03-25 | — | — | EP | disclosed |
| US-4248893-A | Arterial wall cholesterol ester reducing cyclopropanyl-bearing amides | SANDOZ, INC. (US) | 1981-02-03 | — | — | US | disclosed |
| EP-0012183-A2 | 4,4 Dialkyl-4-sila-fatty acid amides, intermediates and process for their preparation and pharmaceutical compositions containing them | SANDOZ AG (CH) | 1980-06-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152489-A1 | NEW PHOSPHINE-BORANE COMPOUND AND METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING HYDROGEN-PHOSPHINE-BORANE COMPOUND | PHOSPHO1, BMP2, BMP1 | LMNA 4656/4885POLB 2717/4885ACHE 892/4885 |
| US-20040019223-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, CYP51A1, WEE1 | LMNA 1331/4885POLB 237/4885ACHE 1264/4885 |
| US-20050272797-A1 | Processes for preparation of bicyclic compounds and intermediates therefor | DCXR, WEE1, CYP51A1 | LMNA 1326/4885POLB 257/4885ACHE 1242/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.