Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.41 |
| ▸ | CD69 | Q07108 | 2/20 | 0.40 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3802709 | 0.84 | TDP1 (0.39) | TDP1KMT2AMAPTTSHRPTGDR2 | |
| SCHEMBL9024624 | 0.81 | PTGS2 (0.50) | KMT2AMAPTPTGDR2PTGDRALDH1A1 | |
| SCHEMBL9025106 | 0.75 | ALDH1A1 (0.46) | KMT2AMAPTTSHRALOX15CD69 | |
| SCHEMBL9023985 | 0.75 | PTGDR2 (0.47) | TSHRPTGDR2 | |
| SCHEMBL162984 | 0.73 | NQO1 (0.36) | TDP1KMT2AMAPTTSHRALDH1A1 | |
| SCHEMBL359664 | 0.73 | LMNA (0.34) | ALDH1A1 | |
| SCHEMBL40485 | 0.71 | ALOX15 (0.65) | TDP1KMT2AMAPTALOX15MCL1 | |
| SCHEMBL30969690 | 0.71 | ALOX15 (0.65) | TDP1KMT2AMAPTALOX15MCL1 | |
| SCHEMBL902241 | 0.70 | ALOX15 (0.53) | TDP1KMT2AMAPTPTGDR2ALOX15 | |
| SCHEMBL159611 | 0.70 | KMT2A (0.35) | KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590944-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2013-05-15 | — | — | EP | claimed |
| WO-2012004722-A1 | 1-PHENYL-SUBSTITUTED HETEROCYCLYL DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-01-12 | — | — | WO | claimed |
| EP-0398179-B1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO (JP) | 1996-01-17 | — | — | EP | disclosed |
| US-5116855-A | Aldose reductase inhibitors; antidiabetic agents | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0398179-A1 | Rhodanine derivatives and pharmaceutical compositions | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1990-11-22 | — | — | EP | disclosed |