Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 11/20 | 0.63 |
| ▸ | BRD9 | Q9H8M2 | 6/20 | 0.63 |
| ▸ | BRD4 | O60885 | 9/20 | 0.61 |
| ▸ | BPTF | Q12830 | 9/20 | 0.54 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.49 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.49 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9982691 | 0.84 | KDM4E (0.64) | KAT2BBRD9BRD4BPTFCNR2 | |
| SCHEMBL3247038 | 0.79 | KAT2B (0.65) | KAT2BBRD9BRD4BPTF | |
| SCHEMBL7160804 | 0.75 | KAT2B (0.74) | KAT2BBRD9BRD4BPTF | |
| Hydrochloric Acid SCHEMBL27570517 | 0.74 | BRD4 (0.38) | KAT2BBRD9BRD4BPTFCNR2 | |
| SCHEMBL9527132 | 0.74 | KAT2B (0.49) | KAT2BBRD9BRD4BPTFCNR2 | |
| SCHEMBL23682690 | 0.74 | BRD4 (1.00) | KAT2BBRD9BRD4BPTFKAT2A | |
| SCHEMBL9531572 | 0.73 | KAT2B (0.58) | KAT2BBRD9BRD4BPTFCNR2 | |
| SCHEMBL27536539 | 0.72 | KAT2B (0.65) | KAT2BBRD9BRD4BPTF | |
| SCHEMBL9528853 | 0.71 | KAT2B (0.60) | KAT2BBRD9BRD4BPTFCNR2 | |
| SCHEMBL9527544 | 0.71 | KAT2B (0.56) | KAT2BBRD9BRD4BPTFCNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417206-B1 | NOVEL 2H-PYRIDAZINE-3-ONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE ACTIVE INGREDIENT | EGIS GYOGYSZERGYAR NYRT (HU) | 2010-05-05 | — | — | EP | disclosed |
| CN-1325489-C | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2007-07-11 | — | — | CN | disclosed |
| US-7183283-B2 | Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | EGIS GYOGYSZERGYAR RT. (HU) | 2007-02-27 | — | — | US | disclosed |
| CN-1289495-C | New piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2006-12-13 | — | — | CN | disclosed |
| US-7098210-B2 | 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient | EGIS Gyógyszergyár Rt. (HU) | 2006-08-29 | — | — | US | disclosed |
| EP-1501823-B1 | NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-12-07 | — | — | EP | disclosed |
| US-20050215560-A1 | Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | EGIS GYOGYSZERGYAR RT. (HU) | 2005-09-29 | — | — | US | disclosed |
| US-6930110-B2 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGIS GYOGYSZERGYAR RT. (HU) | 2005-08-16 | — | — | US | disclosed |
| CN-1630652-A | New piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-06-22 | — | — | CN | disclosed |
| EP-1430047-B1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-02-09 | — | — | EP | disclosed |
| EP-1501823-A1 | NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | EGIS GYOGYSZERGYAR RT. (HU) | 2005-02-02 | — | — | EP | disclosed |
| CN-1571783-A | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGYT GYOGYSZERVEGYESZETI GYAR (HU) | 2005-01-26 | — | — | CN | disclosed |
| US-20040242873-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | EGIS GYOGYSZERGYAR RT. (HU) | 2004-12-02 | — | — | US | disclosed |
| US-20040171619-A1 | Novel 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient | EGIS GYOGYSZERGYAR RT. (HU) | 2004-09-02 | — | — | US | disclosed |
| EP-1430047-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | Egis Gyogyszergyar Rt. (HU) | 2004-06-23 | — | — | EP | disclosed |
| EP-1417206-A1 | NOVEL 2 i H /i -PYRIDAZINE-3-ONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE ACTIVE INGREDIENT | Egis Gyogyszergyar Rt. (HU) | 2004-05-12 | — | — | EP | disclosed |
| WO-2003091244-A1 | NEW PIPERIDINYL-ALKYLAMINO-PYRIDAZINONE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID COMPOUNDS | EGIS Gyógyszergyár Rt. (HU) | 2003-11-06 | — | — | WO | disclosed |
| WO-2003027097-A1 | SUBSTITUTED ALKYLAMINOPYRIDAZINONE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | EGIS Gyógyszergyár Rt. (HU) | 2003-04-03 | — | — | WO | disclosed |
| WO-2003010166-A1 | NOVEL 2H-PYRIDAZINE-3-ONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND A PROCESS FOR THE PREPARATION OF THE ACTIVE INGREDIENT | EGIS Gyógyszergyár Rt. (HU) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242873-A1 | Substituted alkylaminopyridazinone derivatives, process for the preparation thereof and pharmaceutical composition containing the same | CYP3A5, CYP11B1, ADRA1D | KAT2B 1464/4885BRD9 3812/4885BRD4 2449/4885 |
| US-20050215560-A1 | Piperidinyl-alkylamino-pyridazinone derivatives, a process for the preparation thereof and pharmaceutical compositions containing said compounds | H1-0, HTR5A, H1-5 | KAT2B 1267/4885BRD9 2635/4885BRD4 1671/4885 |
| US-20040171619-A1 | Novel 2h-pyridazine-3-one derivatives, pharmaceutical compositions containing the same and a process for the preparation of the active ingredient | HTR2C, HTR5A, HTR3C | KAT2B 3579/4885BRD9 2928/4885BRD4 792/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.