Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ATM | Q13315 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3256725 | 0.92 | GAA (0.33) | SMN1; SMN2LMNAPOLBSIGMAR1GAA | |
| SCHEMBL3255382 | 0.84 | CYP1A2 (0.37) | KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3255401 | 0.83 | P2RX7 (0.39) | SMN1; SMN2KMT2AATMMEN1ALDH1A1 | |
| SCHEMBL3256757 | 0.83 | RPA1 (0.34) | GAA | |
| SCHEMBL3256647 | 0.82 | P2RX7 (0.34) | GAA | |
| SCHEMBL3252454 | 0.82 | ROCK2 (0.35) | LMNAKMT2AMEN1HTTGAA | |
| SCHEMBL3255018 | 0.81 | GAA (0.35) | SMN1; SMN2KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3255755 | 0.80 | ALDH1A1 (0.36) | SMN1; SMN2KDM4EKMT2AMEN1MAPT | |
| SCHEMBL3254057 | 0.79 | TP53 (0.42) | KMT2AATMMEN1POLBMAPT | |
| SCHEMBL3254884 | 0.79 | SIGMAR1 (0.35) | ALDH1A1SIGMAR1TDP1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651613-B1 | 4,5-DIHYDRO-IMIDAZOLE AS P2X7 ION CHANNEL BLOCKERS | AVENTIS PHARMA INC (US) | 2010-05-26 | — | — | EP | disclosed |