Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.37 |
| ▸ | HTR6 | P50406 | 4/20 | 0.36 |
| ▸ | HTR1A | P08908 | 4/20 | 0.35 |
| ▸ | HTR3A | P46098 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR5A | P47898 | 2/20 | 0.35 |
| ▸ | NCF1 | P14598 | 2/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.35 |
| ▸ | HTR3B | O95264 | 2/20 | 0.35 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.35 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1568098 | 0.86 | DRD2 (0.51) | DRD2TRPA1KDM1AADRB1HTR6 | |
| Hydrochloric Acid SCHEMBL1773502 | 0.85 | DRD2 (0.50) | DRD2TRPA1KDM1AADRB1HTR6 | |
| Hydrochloric Acid SCHEMBL4234715 | 0.85 | DRD2 (0.50) | DRD2TRPA1KDM1AADRB1HTR6 | |
| SCHEMBL4787337 | 0.70 | DRD2 (0.44) | DRD2TRPA1KDM1AHTR1AHTR3A | |
| SCHEMBL2032398 | 0.69 | DRD2 (0.39) | DRD2TRPA1KDM1AHTR2A | |
| SCHEMBL4780428 | 0.67 | ADRB1 (0.48) | DRD2TRPA1ADRB1HTR6HTR1A | |
| SCHEMBL3960510 | 0.67 | TRPA1 (0.39) | DRD2TRPA1KDM1AHTR1AHTR3A | |
| SCHEMBL6029951 | 0.66 | HTR1A (0.44) | DRD2ADRB1HTR6HTR1AHTR3A | |
| SCHEMBL5809604 | 0.66 | DRD2 (0.46) | DRD2TRPA1KDM1AHTR6HTR1A | |
| SCHEMBL20876211 | 0.65 | DRD2 (0.42) | DRD2TRPA1ADRB1HTR6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100016284-A1 | COMPOUNDS AND USES THEREOF - 151 | ASTRAZENECA AB (SE) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016284-A1 | COMPOUNDS AND USES THEREOF - 151 | MAPT, BACE1, PSEN1 | DRD2 269/4885TRPA1 2540/4885KDM1A 2124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.