Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 10/20 | 0.42 |
| ▸ | RXRB | P28702 | 9/20 | 0.42 |
| ▸ | RXRG | P48443 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26983245 | 0.89 | TBXA2R (0.46) | LMNAALDH1A1TBXA2RPPARA | |
| SCHEMBL11442711 | 0.80 | L3MBTL1 (0.57) | LMNAL3MBTL1ALDH1A1MMP2PPARA | |
| SCHEMBL4453201 | 0.79 | RXRA (0.45) | LMNAL3MBTL1RXRARXRBRXRG | |
| SCHEMBL1280673 | 0.77 | ALOX15 (0.52) | LMNAL3MBTL1ALDH1A1 | |
| SCHEMBL5517724 | 0.76 | LMNA (0.50) | LMNAL3MBTL1ALDH1A1TBXA2R | |
| SCHEMBL28905370 | 0.72 | L3MBTL1 (0.49) | LMNAL3MBTL1RXRARXRBRXRG | |
| SCHEMBL5513972 | 0.72 | LMNA (0.54) | LMNAL3MBTL1ALDH1A1TBXA2R | |
| SCHEMBL21500720 | 0.72 | LTA4H (0.54) | LMNAL3MBTL1ALDH1A1TBXA2R | |
| SCHEMBL15547011 | 0.72 | HDAC8 (0.35) | LMNAALDH1A1 | |
| SCHEMBL5422564 | 0.72 | ALDH1A1 (0.46) | L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022568-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR EARLY STAGE IDIOPATHIC PULMONARY FIBROSIS | Actelion Pharmaceeuticals Ltd. (CH) | 2010-01-28 | — | — | US | disclosed |