Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | NMT1 | P30419 | 4/20 | 0.44 |
| ▸ | CHKA | P35790 | 6/20 | 0.41 |
| ▸ | HTR6 | P50406 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3237332 | 0.83 | NPC1 (0.46) | ALDH1A1NMT1CHKAFAAH | |
| SCHEMBL1868795 | 0.81 | NMT1 (0.70) | NMT1 | |
| SCHEMBL3236665 | 0.77 | NMT1 (0.63) | NMT1CHKAFAAH | |
| SCHEMBL18904159 | 0.72 | NMT1 (0.48) | ALDH1A1NMT1CHKA | |
| SCHEMBL3232564 | 0.71 | ALDH1A3 (0.44) | FFAR4PTGDRCA2 | |
| SCHEMBL3237444 | 0.69 | NMT1 (0.64) | NMT1CYP2D6 | |
| SCHEMBL21650995 | 0.68 | CHKA (0.58) | ALDH1A1CHKACA2 | |
| SCHEMBL11154024 | 0.67 | KMT2A (0.52) | ALDH1A1FFAR4CA2 | |
| SCHEMBL30963887 | 0.67 | CHRM3 (0.49) | ALDH1A1 | |
| SCHEMBL3231278 | 0.66 | HTR7 (0.49) | HTR6CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828346-B2 | N-myristoyl transferase inhibitors | UNIVERSITY OF DUNDEE (GB) | 2017-11-28 | — | — | US | disclosed |
| EP-2980076-B1 | Pyrazolyl derivatives | UNIV DUNDEE (GB) | 2017-05-31 | — | — | EP | disclosed |
| US-20160060224-A1 | N-MYRISTOYL TRANSFERASE INHIBITORS | UNIVERSITY OF DUNDEE (GB) | 2016-03-03 | — | — | US | disclosed |
| EP-2980076-A1 | PYRAZOLYL DERIVATIVES | University of Dundee (GB) | 2016-02-03 | — | — | EP | disclosed |
| US-9156811-B2 | N-myristoyl transferase inhibitors | Univeristy of Dundee (GB) | 2015-10-13 | — | — | US | disclosed |
| EP-2323987-B1 | N-MYRISTOYL TRANSFERASE INHIBITORS | UNIV DUNDEE (GB) | 2015-06-24 | — | — | EP | disclosed |
| US-20110312921-A1 | N-Myristoyl Transferase Inhibitors | DUNDEE, UNIVERSITY OF (GB) | 2011-12-22 | — | — | US | disclosed |
| WO-2010026365-A1 | N-MYRISTOYL TRANSFERASE INHIBITORS | UNIVERSITY OF DUNDEE (GB) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110312921-A1 | N-Myristoyl Transferase Inhibitors | GNMT, NNMT, SPTLC1 | ALDH1A1 4530/4885NMT1 13/4885CHKA 1398/4885 |
| US-20160060224-A1 | N-MYRISTOYL TRANSFERASE INHIBITORS | GNMT, NNMT, SPTLC1 | ALDH1A1 4530/4885NMT1 13/4885CHKA 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.