Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10937495 | 0.80 | NOS1 (0.36) | FAAHNOS1NOS2 | |
| SCHEMBL3271573 | 0.71 | — | — | |
| SCHEMBL10806119 | 0.68 | — | — | |
| SCHEMBL3265923 | 0.68 | NOS1 (0.31) | NOS1NOS2 | |
| SCHEMBL7744945 | 0.68 | ALDH1A1 (0.57) | FAAHALDH1A1 | |
| SCHEMBL3266225 | 0.67 | — | — | |
| SCHEMBL3267353 | 0.67 | MME (0.36) | — | |
| SCHEMBL6402909 | 0.66 | FAAH (0.40) | FAAHNOS1NOS2ALDH1A1 | |
| SCHEMBL3267280 | 0.64 | — | — | |
| SCHEMBL6260486 | 0.64 | CYP1A2 (0.40) | NOS1NOS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4578474-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1986-03-25 | — | — | US | claimed |
| EP-0042639-B1 | AZIDO, IMIDO, AMIDO AND AMINO DERIVATIVES OF MERCAPTOACYL PROLINES AND PIPECOLIC ACIDS HAVING HYPOTENSIVE ACTIVITY | E.R. Squibb & Sons, Inc. (US) | 1984-08-22 | — | — | EP | claimed |
| US-4454225-A | COUPLERS PREVENTING YELLOW IDSCOLORATION AT UNEXPOSED AREAS | FUJI PHOTO FILM CO., LTD. (JP) | 1984-06-12 | — | — | US | claimed |
| EP-0042639-A2 | Azido, imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids having hypotensive activity | E.R. Squibb & Sons, Inc. (US) | 1981-12-30 | — | — | EP | claimed |
| EP-1517881-B1 | 4-(3,3-DIHALO-ALLYLOXY)PHENOXY ALKYL DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-06-02 | — | — | EP | disclosed |
| US-7414064-B2 | 4-(3,3-dihalo-allyloxy) phenoxy alkyl derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2008-08-19 | — | — | US | disclosed |
| CN-100372849-C | Pyrrolopyrimidines as cysteine protease inhibitors | NOVARTIS AG (CH) | 2008-03-05 | — | — | CN | disclosed |
| US-20070142445-A1 | 4-(3,3-Dihalo-Allyloxy) Phenoxy Alkyl Derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2007-06-21 | — | — | US | disclosed |
| US-7192965-B2 | 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives | SYNGENTA CROP PROTECTION, INC. (US) | 2007-03-20 | — | — | US | disclosed |
| US-20050272649-A1 | Conjoint administration of morphogens and ACE inhibitors in treatment of chronic renal failure | STRYKER CORPORATION | 2005-12-08 | — | — | US | disclosed |
| US-20050245583-A1 | 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives | SYNGENTA CROP PROTECTION, INC. | 2005-11-03 | — | — | US | disclosed |
| EP-1578360-A2 | CONJOINT ADMINISTRATION OF MORPHOGENS AND ACE INHIBITORS IN TREATMENT OF CHRONIC RENAL FAILURE | Curis, Inc. (US) | 2005-09-28 | — | — | EP | disclosed |
| US-4578474-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1986-03-25 | — | — | US | disclosed |
| US-4497953-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1985-02-05 | — | — | US | disclosed |
| EP-0042639-B1 | AZIDO, IMIDO, AMIDO AND AMINO DERIVATIVES OF MERCAPTOACYL PROLINES AND PIPECOLIC ACIDS HAVING HYPOTENSIVE ACTIVITY | E.R. Squibb & Sons, Inc. (US) | 1984-08-22 | — | — | EP | disclosed |
| US-4454225-A | COUPLERS PREVENTING YELLOW IDSCOLORATION AT UNEXPOSED AREAS | FUJI PHOTO FILM CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| US-4390695-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1983-06-28 | — | — | US | disclosed |
| US-4310461-A | HYPTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-01-12 | — | — | US | disclosed |
| EP-0042639-A2 | Azido, imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids having hypotensive activity | E.R. Squibb & Sons, Inc. (US) | 1981-12-30 | — | — | EP | disclosed |
| EP-0042639-A2 | Azido, imido, amido and amino derivatives of mercaptoacyl prolines and pipecolic acids having hypotensive activity | E.R. Squibb & Sons, Inc. (US) | 1981-12-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050272649-A1 | Conjoint administration of morphogens and ACE inhibitors in treatment of chronic renal failure | BMPR2, BMP2, BMP1 | FAAH 1346/4885NOS1 1435/4885NOS2 832/4885 |
| US-20050245583-A1 | 4-(3,3-dihalo-allyloxy)phenoxy alkyl derivatives | DDT, RER1, SCN7A | FAAH 2459/4885NOS1 577/4885NOS2 1002/4885 |
| US-20070142445-A1 | 4-(3,3-Dihalo-Allyloxy) Phenoxy Alkyl Derivatives | DDT, RER1, SCN7A | FAAH 2459/4885NOS1 577/4885NOS2 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.