SCHEMBL32688127

SCHEMBL32688127

N#Cc1c(SCc2nnn[nH]2)[nH]c(=O)c(C(=O)Nc2ccccc2)c1-c1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 6/20 0.45
▸ TP53 P04637 2/20 0.45
▸ RXFP1 Q9HBX9 2/20 0.45
▸ LDHA P00338 4/20 0.42
▸ UBE2N P61088 1/20 0.42
▸ MET P08581 2/20 0.41
▸ KDR P35968 2/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.40
▸ KMT2A Q03164 3/20 0.39
▸ ALDH1A1 P00352 3/20 0.39
▸ MEN1 O00255 2/20 0.39
▸ TDP1 Q9NUW8 2/20 0.39
▸ PPARG P37231 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ NR2E3 Q9Y5X4 1/20 0.39
▸ NCOR2 Q9Y618 1/20 0.39
▸ HPGD P15428 1/20 0.39
▸ POLB P06746 3/20 0.39
▸ LDHB P07195 1/20 0.39
▸ KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL32688110 0.88 MAPT (0.38) MAPTTP53RXFP1LDHAKMT2A
SCHEMBL32688263 0.88 ACMSD (0.42) MAPTLDHAKMT2AALDH1A1MEN1
SCHEMBL32688238 0.86 PTPN1 (0.39) MAPTRXFP1LDHAUBE2NMET
SCHEMBL32688362 0.85 HSD11B1 (0.39) MAPTRXFP1LDHAKMT2AALDH1A1
SCHEMBL32688422 0.83 MAPT (0.38) MAPTRXFP1LDHASMN1; SMN2KMT2A
SCHEMBL32688022 0.81 ALDH1A1 (0.52) MAPTTP53RXFP1LDHAKMT2A
SCHEMBL32688374 0.81 NPC1 (0.40) MAPTRXFP1LDHAUBE2NMET
SCHEMBL32688269 0.81 HSD11B1 (0.45) RXFP1LDHASMN1; SMN2KMT2AALDH1A1
SCHEMBL32688235 0.80 HSD11B1 (0.45) RXFP1LDHASMN1; SMN2KMT2AALDH1A1
SCHEMBL32688008 0.79 MEN1 (0.42) KMT2AALDH1A1MEN1HPGDPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors ORSOBIO INC (US) 2026-03-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260078105-A1 Novel Aminocarboxymuconate Semialdehyde Decarboxylase Inhibitors CPT1B, CBR1, MUSK MAPT 4018/4885TP53 4273/4885RXFP1 2355/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback