Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 14/20 | 0.83 |
| ▸ | PTGES | O14684 | 1/20 | 0.69 |
| ▸ | PPARG | P37231 | 3/20 | 0.59 |
| ▸ | PPARA | Q07869 | 2/20 | 0.59 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 2/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | PHLPP1 | O60346 | 1/20 | 0.56 |
| ▸ | ILK | Q13418 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29465604 | 1.00 | ALOX5 (0.83) | ALOX5PTGESPPARGPPARANR1I2 | |
| Gamma-Tocotrienol SCHEMBL16430897 | 1.00 | ALOX5 (0.83) | ALOX5PTGESPPARGPPARANR1I2 | |
| Gamma-Tocotrienol SCHEMBL3272929 | 1.00 | ALOX5 (0.83) | ALOX5PTGESPPARGPPARANR1I2 | |
| Gamma-Tocotrienol SCHEMBL3270923 | 1.00 | ALOX5 (0.83) | ALOX5PTGESPPARGPPARANR1I2 | |
| Gamma-Tocotrienol SCHEMBL29354672 | 1.00 | ALOX5 (0.83) | ALOX5PTGESPPARGPPARANR1I2 | |
| SCHEMBL17523133 | 0.93 | ALOX5 (0.71) | ALOX5PTGESPPARGPPARANR1I2 | |
| SCHEMBL12368109 | 0.93 | ALOX5 (0.71) | ALOX5PTGESPPARGPPARANR1I2 | |
| SCHEMBL18583914 | 0.93 | ALOX5 (0.88) | ALOX5PTGESPPARGPPARANR1I2 | |
| SCHEMBL18583915 | 0.91 | ALOX5 (1.00) | ALOX5PTGESPPARGPPARANR1I2 | |
| SCHEMBL16589599 | 0.90 | ALOX5 (0.68) | ALOX5PTGESPPARGPPARANR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3450431-B1 | PROCESS FOR THE PRODUCTION OF ALPHA-TOCOTRIENOL AND DERIVATIVES | PTC THERAPEUTICS INC (US) | 2023-09-13 | — | — | EP | disclosed |
| US-11578186-B2 | Polypropylene composition for use in BOPP application, a process for preparing BOPP films and said BOPP film | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2023-02-14 | — | — | US | disclosed |
| US-11560364-B2 | Methods for enriching alpha-tocotrienol from mixed tocol compositions | PTC THERAPEUTICS, INC. (US) | 2023-01-24 | — | — | US | disclosed |
| WO-2022129435-A1 | MILK REPLACER COMPRISING ANIMAL-FREE FORMULATIONS OF FAT-SOLUBLE VITAMINS | DSM IP ASSETS B.V. (NL) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022129433-A1 | MILK REPLACER COMPRISING ANIMAL-FREE FORMULATIONS OF FAT-SOLUBLE VITAMINS | DSM IP ASSETS B.V. (NL) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022112585-A1 | NEW SUGAR-FREE FORMULATIONS, THEIR MANUFACTURE AND USE | DSM IP ASSETS B.V. (NL) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022112586-A1 | NEW SUGAR-FREE FORMULATIONS, THEIR MANUFACTURE AND USE | DSM IP ASSETS B.V. (NL) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022112592-A1 | NEW FORMULATIONS WITH REDUCED ANTIOXIDANT CONTENT, THEIR MANUFACTURE AND USE | DSM IP ASSETS B.V. (NL) | 2022-06-02 | — | — | WO | disclosed |
| WO-2022112587-A1 | NEW FORMULATIONS WITH REDUCED ANTIOXIDANT CONTENT, THEIR MANUFACTURE AND USE | DSM IP ASSETS B.V. (NL) | 2022-06-02 | — | — | WO | disclosed |
| US-20220160759-A1 | NOVEL COMPOSITIONS FOR TREATING COLITIS AND/OR PREVENTING COLON CANCER | PURDUE RESEARCH FOUNDATION (US) | 2022-05-26 | — | — | US | disclosed |
| US-6864280-B2 | Hypotensive agents; cardiovascular disorders | EISAI CO., LTD. (JP) | 2005-03-08 | — | — | US | disclosed |
| US-20040176311-A1 | Composition and method for treating cancer | MO HUANBIAO (US) | 2004-09-09 | — | — | US | disclosed |
| US-20040110848-A1 | Method and kit for treating cancer | PEFFLEY DENNIS M | 2004-06-10 | — | — | US | disclosed |
| US-20030139467-A1 | Diuretics containing y-tocotrienol | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2003-07-24 | — | — | US | disclosed |
| EP-1270004-A1 | DIURETICS CONTAINING GAMMA-TOCOTRIENOL | Eisai Co., Ltd. (JP) | 2003-01-02 | — | — | EP | disclosed |
| US-6441029-B1 | D-.GAMMA.-TOCOTRIENOL, 2-DESMETHYLTOCOTRIENOL, D-.DELTA.-TOCOTRIENOL OR D-TOCOTRIENOL AND LOVASTATIN | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2002-08-27 | — | — | US | disclosed |
| EP-1044687-A1 | POWDERS CONTAINING TOCOTRIENOLS, PROCESS FOR PRODUCING THE SAME AND TABLETS PREPARED BY COMPRESSION MOLDING THE SAME | FUJI CHEMICAL INDUSTRY CO., LTD. (JP) | 2000-10-18 | — | — | EP | disclosed |
| US-5348974-A | Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-09-20 | — | — | US | disclosed |
| US-5217992-A | Administering mixtures of tocotrienols to reduce serum cholesterol levels | BRISTOL-MYERS SQUIBB COMPANY (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0421419-A2 | Tocotrienols in the treatment of hypercholesterolemia, hyperlipidemia and thromboembolic disorders | Bristol-Myers Squibb Company (US) | 1991-04-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11560364-B2 | Methods for enriching alpha-tocotrienol from mixed tocol compositions | TTPA, GSTO1, CCT8 | ALOX5 345/4885PTGES 64/4885PPARG 492/4885 |
| US-20220160759-A1 | NOVEL COMPOSITIONS FOR TREATING COLITIS AND/OR PREVENTING COLON CANCER | LBR, LTA, IL23R | ALOX5 51/4885PTGES 420/4885PPARG 216/4885 |
| US-20030139467-A1 | Diuretics containing y-tocotrienol | SLC26A4, SLC5A1, REN | ALOX5 170/4885PTGES 159/4885PPARG 611/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.