Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 10/20 | 0.68 |
| ▸ | CA2 | P00918 | 10/20 | 0.68 |
| ▸ | CA9 | Q16790 | 7/20 | 0.68 |
| ▸ | CA4 | P22748 | 6/20 | 0.68 |
| ▸ | CA12 | O43570 | 5/20 | 0.68 |
| ▸ | CA6 | P23280 | 5/20 | 0.68 |
| ▸ | CA5A | P35218 | 5/20 | 0.68 |
| ▸ | CA7 | P43166 | 5/20 | 0.68 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.68 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.68 |
| ▸ | CA3 | P07451 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | PTGES2 | Q9H7Z7 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3778122 | 0.92 | CA1 (0.62) | CA1CA2CA9CA4CA12 | |
| SCHEMBL2777246 | 0.83 | CA2 (0.46) | CA1CA2CA9CA4CA12 | |
| SCHEMBL1807804 | 0.83 | CA1 (0.79) | CA1CA2CA9CA4CA12 | |
| SCHEMBL2777430 | 0.83 | CA1 (0.54) | CA1CA2CA9CA4CA12 | |
| SCHEMBL29376122 | 0.81 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| SCHEMBL310205 | 0.81 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| SCHEMBL30659050 | 0.81 | CA1 (1.00) | CA1CA2CA9CA4CA12 | |
| SCHEMBL2777121 | 0.79 | CA2 (0.46) | CA1CA2CA9CA4CA12 | |
| SCHEMBL20485809 | 0.79 | CA1 (0.55) | CA1CA2CA9CA4CA12 | |
| SCHEMBL1699945 | 0.77 | CA1 (0.57) | CA1CA2CA9CA4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250360142-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | RHYTHM PHARMACEUTICALS INC (US) | 2025-11-27 | — | — | US | disclosed |
| EP-4605383-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | Rhythm Pharmaceuticals, Inc. (US) | 2025-08-27 | — | — | EP | disclosed |
| WO-2024086252-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | RHYTHM PHARMACEUTICALS, INC. (US) | 2024-04-25 | — | — | WO | disclosed |
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-04-08 | — | — | US | disclosed |
| EP-2121569-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008074755-A2 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-06-26 | — | — | WO | disclosed |
| CN-1081633-C | 1,2, 4-benzothiadiazine derivatives, method for preparing same and use thereof | NOVO NORDISK AS (DK) | 2002-03-27 | — | — | CN | disclosed |
| US-6242443-B1 | 1,2,4-benzothiadiazine derivatives, their preparation and use | NOVO NORDISK AIS (DK) | 2001-06-05 | — | — | US | disclosed |
| CN-1222910-A | 1,2, 4-benzothiadiazine derivatives, method for preparing same and use thereof | NOVO NORDISK AS (DK) | 1999-07-14 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087496-A1 | NOVEL CINNAMIC AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | TRPV1, TRPA1, TRPM8 | CA1 1200/4885CA2 216/4885CA9 3282/4885 |
| US-20250360142-A1 | NOVEL ATP-SENSITIVE POTASSIUM CHANNEL POTENTIATORS, THEIR PREPARATION AND USE | KCNJ11, ATP1A2, ATP1A3 | CA1 3276/4885CA2 647/4885CA9 2203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.