Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | TPH1 | P17752 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL309144 | 0.89 | SMN1; SMN2 (0.43) | HDAC3HDAC1HDAC2HDAC6NPC1 | |
| SCHEMBL308835 | 0.79 | TPH1 (0.52) | HDAC3HDAC1HDAC2HDAC6SMN1; SMN2 | |
| SCHEMBL22191398 | 0.78 | ALDH1A1 (0.57) | HDAC3HDAC1HDAC2HDAC6SMN1; SMN2 | |
| SCHEMBL3274458 | 0.75 | AKT1 (0.45) | HDAC3HDAC1HDAC2HDAC6BRD4 | |
| SCHEMBL3980734 | 0.69 | ALDH1A1 (0.46) | HDAC3HDAC1HDAC2HDAC6BRD4 | |
| SCHEMBL16381665 | 0.68 | STIM1 (0.43) | NPC1PKMRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL4729595 | 0.68 | HDAC6 (1.00) | HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL308051 | 0.68 | TPH1 (0.51) | MEN1KMT2ALMNAMAPTTPH1 | |
| SCHEMBL6779496 | 0.67 | FFAR1 (0.55) | HDAC3HDAC1HDAC2HDAC6BRD4 | |
| SCHEMBL6827809 | 0.67 | SMN1; SMN2 (0.46) | RAB9ASMN1; SMN2MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102186476-A | Tryptophan hydroxylase inhibitors and methods of their use | LEXICON PHARMACEUTICALS INC | 2011-09-14 | — | — | CN | disclosed |
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | LEXICON PHARMACEUTICALS, INC. | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | TPH1, TPH2, HNMT | HDAC3 1212/4885HDAC1 1157/4885HDAC2 986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.