Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.45 |
| ▸ | AKT2 | P31751 | 1/20 | 0.45 |
| ▸ | TPH1 | P17752 | 2/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | PIM1 | P11309 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.39 |
| ▸ | HIPK1 | Q86Z02 | 2/20 | 0.39 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.39 |
| ▸ | HIPK3 | Q9H422 | 2/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274402 | 0.75 | HDAC3 (0.51) | TPH1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL870470 | 0.71 | TPH1 (0.82) | TPH1 | |
| SCHEMBL28552255 | 0.68 | AKT2 (0.72) | AKT1AKT2CHEK1PIM1CHEK2 | |
| SCHEMBL6520649 | 0.68 | AKT2 (0.50) | AKT1AKT2BCL2L1ROCK2ADRA1D | |
| SCHEMBL82741 | 0.66 | AKT2 (1.00) | AKT1AKT2CHEK1PIM1CHEK2 | |
| Benzene SCHEMBL28198087 | 0.66 | AKT2 (1.00) | AKT1AKT2CHEK1PIM1CHEK2 | |
| SCHEMBL10648059 | 0.66 | HDAC3 (0.53) | TPH1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL21142334 | 0.66 | AKT2 (0.53) | AKT1AKT2CHEK1PIM1CHEK2 | |
| SCHEMBL309144 | 0.66 | SMN1; SMN2 (0.43) | TPH1HDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL3980734 | 0.65 | ALDH1A1 (0.46) | HDAC3HDAC1HDAC2HDAC6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102186476-A | Tryptophan hydroxylase inhibitors and methods of their use | LEXICON PHARMACEUTICALS INC | 2011-09-14 | — | — | CN | disclosed |
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | LEXICON PHARMACEUTICALS, INC. | 2010-04-08 | — | — | US | disclosed |
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | LEXICON PHARMACEUTICALS, INC. | 2010-04-08 | — | — | US | disclosed |
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | LEXICON PHARMACEUTICALS, INC. | 2010-04-08 | — | — | US | disclosed |
| WO-2010039957-A1 | TRYPTOPHAN HYDROXYLASE INHIBITORS AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100087433-A1 | Methods of inhibiting tryptophan hydroxylase | TPH1, TPH2, HNMT | AKT1 3593/4885AKT2 3327/4885TPH1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.